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Chemical Compound Review

ritonavir     1,3-thiazol-5-ylmethyl N-[(2S,3S,5R)-3...

Synonyms: Norvir, Ritonavire, CHEMBL163, SureCN6679, Norvir Sec, ...
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High impact information on ritonavir

  • RESULTS: Simultaneous coadministration of ESO 20 mg qd with either FPV 1400 mg bid or FPV 700 mg bid + RTV 100 mg bid had no effect on steady-state amprenavir pharmacokinetics [1].

Associations of ritonavir with other chemical compounds


Analytical, diagnostic and therapeutic context of ritonavir

  • Baseline viral load and the number of mutations on the protease coding region (PRO) were associated with the virological outcome of APV/RTV-based regimens [4].


  1. Coadministration of esomeprazole with fosamprenavir has no impact on steady-state plasma amprenavir pharmacokinetics. Shelton, M.J., Ford, S.L., Borland, J., Lou, Y., Wire, M.B., Min, S.S., Xue, Z.G., Yuen, G. J. Acquir. Immune Defic. Syndr. (2006) [Pubmed]
  2. Human immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from human macrophage-derived foam cells. Wang, X., Mu, H., Chai, H., Liao, D., Yao, Q., Chen, C. Am. J. Pathol. (2007) [Pubmed]
  3. Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. Kharasch, E.D., Bedynek, P.S., Walker, A., Whittington, D., Hoffer, C. Clin. Pharmacol. Ther. (2008) [Pubmed]
  4. Efficacy, safety and predictive factors of virological success of a boosted amprenavir-based salvage regimen in heavily antiretroviral-experienced HIV-1-infected patients. Clevenbergh, P., Boulmé, R., Kirstetter, M., Dellamonica, P. HIV Med. (2004) [Pubmed]
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