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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Conformationally restrained aromatic analogues of fosmidomycin and FR900098.

The synthesis and in-vitro antimalarial activity of conformationally restrained bis(pivaloyloxymethyl) ester analogues of the natural product fosmidomycin is presented. In contrast to alpha-aryl-substituted analogues, conformationally restrained aromatic analogues exhibit only moderate in-vitro antimalarial activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum. The most active derivative displays an IC(50) value of 47 microM.[1]

References

  1. Conformationally restrained aromatic analogues of fosmidomycin and FR900098. Kurz, T., Schlüter, K., Pein, M., Behrendt, C., Bergmann, B., Walter, R.D. Arch. Pharm. (Weinheim) (2007) [Pubmed]
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