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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fluorescence diagnosis in keratinocytic intraepidermal neoplasias.

BACKGROUND: As different tissue types have distinct capabilities to accumulate protoporphyrin-IX, fluorescence diagnosis with aminolevulinic acid-induced porphyrin (FDAP) could be used to discriminate between different tissue types. OBJECTIVE: Protoporphyrin-IX accumulation and proliferation were studied in cutaneous squamous (pre)malignancies to see whether FDAP could be used to discriminate between different stages of keratinocytic intraepidermal neoplasia or proliferative status. METHODS: FDAP was performed in 14 patients (86 lesions) and biopsy specimens were taken, on which (immuno)histochemistry was performed for histopathologic classification and assessment of Ki67-antigen expression. Stratum corneum thickness was also measured. RESULTS: The fluorescence ratio (lesional:nonlesional skin) showed neither significant differences between the different keratinocytic intraepidermal neoplasia stages, nor between different levels of Ki67-antigen expression. Macroscopic fluorescence intensity and stratum corneum thickness were negatively correlated. LIMITATIONS: Relatively few malignancies were biopsied. CONCLUSIONS: With FDAP we were not able to discriminate between keratinocytic intraepidermal neoplasia lesions or proliferative activity. However, hyperkeratosis appeared to be an important determinant in variations in macroscopic fluorescence intensity.[1]


  1. Fluorescence diagnosis in keratinocytic intraepidermal neoplasias. Smits, T., Kleinpenning, M.M., Blokx, W.A., van de Kerkhof, P.C., van Erp, P.E., Gerritsen, M.J. J. Am. Acad. Dermatol. (2007) [Pubmed]
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