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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Sanchorawala, V. et al.

Vaishali Sanchorawala, Martha Skinner, Karen Quillen, Kathleen T. Finn, Gheorghe Doros, David C. Seldin,

Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation.

Long-term survival and outcome were determined for 80 patients with immunoglobulin light chain (AL) amyloidosis treated with high-dose melphalan and stem cell transplantation (HDM/SCT) more than 10 years ago. Seventeen (21%) patients died within the first year of treatment, of treatment-related complications (14%) or progressive disease (8%). Of the 63 surviving evaluable patients at one year, 32 (51%) achieved a complete hematologic response (CR). For all 80 patients, the median survival was 57 months (4.75 yrs). The median survival exceeds 10 years for patients achieving a CR after HDM/SCT, compared with 50 months for those not achieving a CR (P < .001). In conclusion, HDM/SCT leads to durable remissions and prolonged survival, particularly for those patients who achieve a hematologic CR.[1]

References

Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation. Sanchorawala, V., Skinner, M., Quillen, K., Finn, K.T., Doros, G., Seldin, D.C. Blood (2007) [Pubmed]

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