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Disease relevance of Amyloidosis


Psychiatry related information on Amyloidosis


High impact information on Amyloidosis


Chemical compound and disease context of Amyloidosis


Biological context of Amyloidosis


Anatomical context of Amyloidosis

  • To investigate the role of fixed macrophages in amyloidogenesis and to establish more definitively that amyloid deposition is attributable to faulty processing of the precursor protein rather than aberrant synthesis, secondary amyloidosis was induced in C57BL/6J mice by serial injections of casein [23].
  • Since some forms of secondary amyloidosis are caused by deposition in tissues of peptides derived from the SAA and leukocytes seem to be involved in this process, we investigated the effect of human SAA on human monocytes and polymorphonuclear cells (PMN) [24].
  • PATIENTS: 65 patients with AL amyloidosis and urinary protein excretion greater than 1 g/24 h who received dose-intensive intravenous melphalan and autologous blood stem-cell transplantation between 1 July 1994 and 30 June 1998 [25].
  • Primary (AL) amyloidosis is a plasma cell dyscrasia characterized by extracellular deposition of monoclonal light-chain variable region (V) fragments in the form of amyloid fibrils [26].
  • Neuropathologically, the common denominator is a cerebral prion protein amyloidosis; however, there is significant variability in the pattern of amyloid deposition in regions of the central nervous system among reported families [27].

Gene context of Amyloidosis


Analytical, diagnostic and therapeutic context of Amyloidosis


  1. Resolution of acquired factor X deficiency and amyloidosis with melphalan and prednisone therapy. Camoriano, J.K., Greipp, P.R., Bayer, G.K., Bowie, E.J. N. Engl. J. Med. (1987) [Pubmed]
  2. Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa. Schmaier, A.H., Dahl, L.D., Rozemuller, A.J., Roos, R.A., Wagner, S.L., Chung, R., Van Nostrand, W.E. J. Clin. Invest. (1993) [Pubmed]
  3. Systemic senile amyloidosis. Identification of a new prealbumin (transthyretin) variant in cardiac tissue: immunologic and biochemical similarity to one form of familial amyloidotic polyneuropathy. Gorevic, P.D., Prelli, F.C., Wright, J., Pras, M., Frangione, B. J. Clin. Invest. (1989) [Pubmed]
  4. Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin. Maury, C.P. J. Clin. Invest. (1991) [Pubmed]
  5. Partial amino acid sequence homology between an heredofamilial amyloid protein and human plasma prealbumin. Benson, M.D. J. Clin. Invest. (1981) [Pubmed]
  6. Alzheimer's disease: a cell biological perspective. Kosik, K.S. Science (1992) [Pubmed]
  7. Real and imagined clinicopathological limits of "prion dementia". Brown, P., Kaur, P., Sulima, M.P., Goldfarb, L.G., Gibbs, C.J., Gajdusek, D.C. Lancet (1993) [Pubmed]
  8. Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin. Abraham, C.R., Shirahama, T., Potter, H. Neurobiol. Aging (1990) [Pubmed]
  9. The biological and chemical basis for tissue-selective amyloid disease. Sekijima, Y., Wiseman, R.L., Matteson, J., Hammarström, P., Miller, S.R., Sawkar, A.R., Balch, W.E., Kelly, J.W. Cell (2005) [Pubmed]
  10. A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine. Kyle, R.A., Gertz, M.A., Greipp, P.R., Witzig, T.E., Lust, J.A., Lacy, M.Q., Therneau, T.M. N. Engl. J. Med. (1997) [Pubmed]
  11. Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans. Jacobson, D.R., Pastore, R.D., Yaghoubian, R., Kane, I., Gallo, G., Buck, F.S., Buxbaum, J.N. N. Engl. J. Med. (1997) [Pubmed]
  12. Amyloid fibrils in Gerstmann-Sträussler-Scheinker disease (Indiana and Swedish kindreds) express only PrP peptides encoded by the mutant allele. Tagliavini, F., Prelli, F., Porro, M., Rossi, G., Giaccone, G., Farlow, M.R., Dlouhy, S.R., Ghetti, B., Bugiani, O., Frangione, B. Cell (1994) [Pubmed]
  13. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Levy, E., Carman, M.D., Fernandez-Madrid, I.J., Power, M.D., Lieberburg, I., van Duinen, S.G., Bots, G.T., Luyendijk, W., Frangione, B. Science (1990) [Pubmed]
  14. Hereditary renal amyloidosis with a novel variant fibrinogen. Uemichi, T., Liepnieks, J.J., Benson, M.D. J. Clin. Invest. (1994) [Pubmed]
  15. Hamster female protein, a sex-limited pentraxin, is a constituent of Syrian hamster amyloid. Coe, J.E., Ross, M.J. J. Clin. Invest. (1985) [Pubmed]
  16. Effect of a single dose of dimethyl sulphoxide on renal amyloidosis. Ravid, M., Keizman, I.K., Sohar, E. Lancet (1977) [Pubmed]
  17. Specific chemical dissociation of fibrillar and non-fibrillar components of amyloid deposits. Hind, C.R., Collins, P.M., Caspi, D., Baltz, M.L., Pepys, M.B. Lancet (1984) [Pubmed]
  18. Diverse gene expression for isotypes of murine serum amyloid A protein during acute phase reaction. Yamamoto, K., Shiroo, M., Migita, S. Science (1986) [Pubmed]
  19. Amyloidogenesis. One serum amyloid A isotype is selectively removed from the circulation. Meek, R.L., Hoffman, J.S., Benditt, E.P. J. Exp. Med. (1986) [Pubmed]
  20. A genetic marker for systemic amyloidosis in juvenile arthritis. Woo, P., O'Brien, J., Robson, M., Ansell, B.M. Lancet (1987) [Pubmed]
  21. Frequency and genetic background of the position 122 (Val----Ile) variant transthyretin gene in the black population. Jacobson, D.R., Reveille, J.D., Buxbaum, J.N. Am. J. Hum. Genet. (1991) [Pubmed]
  22. Primary structure of an amyloid prealbumin variant in familial polyneuropathy of Jewish origin. Pras, M., Prelli, F., Franklin, E.C., Frangione, B. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  23. Impaired Kupffer cell function precedes development of secondary amyloidosis. Fuks, A., Zucker-Franklin, D. J. Exp. Med. (1985) [Pubmed]
  24. Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. Badolato, R., Wang, J.M., Murphy, W.J., Lloyd, A.R., Michiel, D.F., Bausserman, L.L., Kelvin, D.J., Oppenheim, J.J. J. Exp. Med. (1994) [Pubmed]
  25. Effect of dose-intensive intravenous melphalan and autologous blood stem-cell transplantation on al amyloidosis-associated renal disease. Dember, L.M., Sanchorawala, V., Seldin, D.C., Wright, D.G., LaValley, M., Berk, J.L., Falk, R.H., Skinner, M. Ann. Intern. Med. (2001) [Pubmed]
  26. Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment. Perfetti, V., Casarini, S., Palladini, G., Vignarelli, M.C., Klersy, C., Diegoli, M., Ascari, E., Merlini, G. Blood (2002) [Pubmed]
  27. Gerstmann-Sträussler-Scheinker disease and the Indiana kindred. Ghetti, B., Dlouhy, S.R., Giaccone, G., Bugiani, O., Frangione, B., Farlow, M.R., Tagliavini, F. Brain Pathol. (1995) [Pubmed]
  28. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Herzig, M.C., Winkler, D.T., Burgermeister, P., Pfeifer, M., Kohler, E., Schmidt, S.D., Danner, S., Abramowski, D., Stürchler-Pierrat, C., Bürki, K., van Duinen, S.G., Maat-Schieman, M.L., Staufenbiel, M., Mathews, P.M., Jucker, M. Nat. Neurosci. (2004) [Pubmed]
  29. Linkage of protection against amyloid fibril formation in the mouse to a single, autosomal dominant gene. Gonnerman, W.A., Elliott-Bryant, R., Carreras, I., Sipe, J.D., Cathcart, E.S. J. Exp. Med. (1995) [Pubmed]
  30. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Tan, J., Town, T., Crawford, F., Mori, T., DelleDonne, A., Crescentini, R., Obregon, D., Flavell, R.A., Mullan, M.J. Nat. Neurosci. (2002) [Pubmed]
  31. MEFV-Gene analysis in armenian patients with Familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications. Cazeneuve, C., Sarkisian, T., Pêcheux, C., Dervichian, M., Nédelec, B., Reinert, P., Ayvazyan, A., Kouyoumdjian, J.C., Ajrapetyan, H., Delpech, M., Goossens, M., Dodé, C., Grateau, G., Amselem, S. Am. J. Hum. Genet. (1999) [Pubmed]
  32. Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. Touitou, I., Sarkisian, T., Medlej-Hashim, M., Tunca, M., Livneh, A., Cattan, D., Yalçinkaya, F., Ozen, S., Majeed, H., Ozdogan, H., Kastner, D., Booth, D., Ben-Chetrit, E., Pugnère, D., Michelon, C., Séguret, F., Gershoni-Baruch, R. Arthritis Rheum. (2007) [Pubmed]
  33. Evaluation of systemic amyloidosis by scintigraphy with 123I-labeled serum amyloid P component. Hawkins, P.N., Lavender, J.P., Pepys, M.B. N. Engl. J. Med. (1990) [Pubmed]
  34. Experimental systemic amyloidosis induced by immunization with syngeneic organ extracts in mice. Mori, Y., Akikusa, B., Mori, T., Ueda, S., Iesato, K., Yoshida, H., Ogawa, M., Kato, I., Wakashin, Y., Wakashin, M. J. Exp. Med. (1986) [Pubmed]
  35. beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis. Miyata, T., Oda, O., Inagi, R., Iida, Y., Araki, N., Yamada, N., Horiuchi, S., Taniguchi, N., Maeda, K., Kinoshita, T. J. Clin. Invest. (1993) [Pubmed]
  36. Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis. Holmgren, G., Ericzon, B.G., Groth, C.G., Steen, L., Suhr, O., Andersen, O., Wallin, B.G., Seymour, A., Richardson, S., Hawkins, P.N. Lancet (1993) [Pubmed]
  37. Pulmonary amyloidosis. The Mayo Clinic experience from 1980 to 1993. Utz, J.P., Swensen, S.J., Gertz, M.A. Ann. Intern. Med. (1996) [Pubmed]
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