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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Synthesis of (-)-chaetominine.

The tricyclic hydroxy imidazolidinone was converted to chaetominine in seven steps in 22% overall yield. The key step was the construction of the delta-lactam by heating an amino ester with a catalytic amount of DMAP in toluene at reflux.[1]


  1. Synthesis of (-)-chaetominine. Snider, B.B., Wu, X. Org. Lett. (2007) [Pubmed]
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