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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Correlation of estrogen sulfotransferase activity and proliferation in normal and carcinomatous human breast. A hypothesis.

BACKGROUND: Sulfotransferases are present in normal and cancerous human breast tissues. The purpose of this article is to present a hypothetical correlation of sulfotransferase activity with proliferation in breast cancer. MATERIALS AND METHODS: Sulfotransferases were evaluated in breast cancer cells by determining the transformation of non-conjugated estrogens to the sulfates. Proliferation was evaluated by the action on cell growth or the size of a transplanted tumor. The effect was obtained using the progestins: nomegestrol acetate, promegestone, and medrogestone, as well as tibolone and its metabolites at concentrations of 5 x 10(-5) to 5 x 10(-9) M. RESULTS: A possible correlation of sulfotransferase activity stimulation and cell growth inhibition provoked by the various progestins used, or by tibolone and its metabolites was shown. CONCLUSION: It is suggested that the antiproliferative effect of these compounds could be related to the decrease of bioactive estradiol by the formation of its biologically inactive sulfate as a consequence of the stimulatory effect by the various progestins or tibolone on sulfotransferase activity.[1]

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