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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.

Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice. Cystatin C expression twice that of the endogenous mouse cystatin C was sufficient to substantially diminish amyloid-beta deposition. Thus, cystatin C has a protective role in Alzheimer's disease pathogenesis, and modulation of cystatin C concentrations may have therapeutic implications for the disease.[1]

References

  1. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Mi, W., Pawlik, M., Sastre, M., Jung, S.S., Radvinsky, D.S., Klein, A.M., Sommer, J., Schmidt, S.D., Nixon, R.A., Mathews, P.M., Levy, E. Nat. Genet. (2007) [Pubmed]
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