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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Comparison of vascularization of Medpor and Medpor-Plus orbital implants: a prospective, randomized study.

PURPOSE: To compare vascularization of porous polyethylene (Medpor) and porous polyethylene with synthetic bone graft particulate (Medpor-Plus) orbital implants following enucleation. METHODS: Prospective, randomized study involving 10 patients. A standard enucleation procedure was performed, and each patient was randomized to receive either Medpor or Medpor-Plus orbital implant with anterior scleral cap technique. Gadolinium-enhanced, 3-Tesla MRI was performed at 1.5 months, 3 months, and 4.5 months following surgery. Implant vascularization was calculated in axial, coronal, and sagittal planes with manual planimetric method using postcontrast T1-weighted Digital Imaging and Communications in Medicine images. RESULTS: The mean area of implant vascularization at 1.5 months, 3 months, and 4.5 months for Medpor implants was 58%, 70%, and 75%, respectively, and for Medpor-Plus implants was 69%, 76%, and 85%, respectively. The mean vascularization of Medpor-Plus implants was more than Medpor implants at 1.5 months (p = 0.008), 3 months (p = 0.09), and 4.5 months (p = 0.003). The difference between the 2 groups assessed by repeated measures analysis of variance was statistically significant (p < 0.0001). During the mean follow-up of 36.7 months (range, 18-43 months), 1 patient in the Medpor group had implant exposure that responded to scleral patch graft. CONCLUSIONS: Implant vascularization is faster with Medpor-Plus implants compared with Medpor implants when assessed by a planimetric method using 3 Tesla MRI. The addition of synthetic bone graft particulate (Novabone) to porous polyethylene may enhance implant vascularization.[1]


  1. Comparison of vascularization of Medpor and Medpor-Plus orbital implants: a prospective, randomized study. Naik, M.N., Murthy, R.K., Honavar, S.G. Ophthal. Plast. Reconstr. Surg (2007) [Pubmed]
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