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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TAMpering with toll-like receptor signaling.

Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3.[1]

References

  1. TAMpering with toll-like receptor signaling. O'Neill, L.A. Cell (2007) [Pubmed]
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