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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

How to identify a pharmacophore.

The inhibition of chitinases by argifin and progressively dissected analogs had been studied by a combination of kinetic and crystallographic methods (Andersen et al., 2008). This work also leads to a general understanding of structure-activity relationships for inhibitors with one distinct pharmacophor.[1]


  1. How to identify a pharmacophore. Prinz, H. Chem. Biol. (2008) [Pubmed]
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