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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

5-HT1A-agonistic properties of naftopidil, a novel antihypertensive drug.

Naftopidil, a novel antihypertensive compound, possesses 5-HT1A agonistic properties in addition to being an alpha 1-adrenoceptor antagonist. The IC50 values for alpha 1-adrenoceptors (235 nmol/l) and for 5-HT1A receptors (108 nmol/l) lie in the same concentration range. The reduction in blood pressure of anesthetized cats by 8-OH-DPAT and urapidil was completely abolished by spiroxatrine, a 5-HT1A antagonist. However, the decreases in blood pressure induced by naftopidil were only partly antagonized by spiroxatrine.[1]


  1. 5-HT1A-agonistic properties of naftopidil, a novel antihypertensive drug. Borbe, H.O., Metzenauer, P., Szelenyi, I. Eur. J. Pharmacol. (1991) [Pubmed]
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