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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Blood Pressure

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Disease relevance of Blood Pressure


Psychiatry related information on Blood Pressure


High impact information on Blood Pressure


Chemical compound and disease context of Blood Pressure


Biological context of Blood Pressure

  • The ischemic threshold--assessed by multiplying the heart rate by the systolic blood pressure at a 1-mm depression of the ST segment during exercise testing--increased by 19 percent after the administration of nitroglycerin (P less than 0.05) and decreased by 18 percent after the administration of ergonovine (P less than 0.01) [20].
  • The role of Smad6 in the homeostasis of the adult cardiovascular system is indicated by the development of aortic ossification and elevated blood pressure in viable mutants [21].
  • We conclude that microalbuminuria predicts the development of diabetic nephropathy and that elevated glomerular filtration rates and increased blood pressure may also contribute to this progression [22].
  • Treatment with enalapril normalized blood pressure and muscle sympathetic-nerve activity (at 23+/-10 bursts per minute) in the patients and shifted the baroreflex curve to the left, reflecting normal blood-pressure levels, without significantly changing sensitivity (-2.3+/-1.8 bursts per minute per mm Hg, P=0.96) [23].
  • To evaluate the functional importance of the altered prostacyclin production, we studied the responses of renal blood flow and blood pressure to the calcium infusion [24].

Anatomical context of Blood Pressure


Associations of Blood Pressure with chemical compounds


Gene context of Blood Pressure

  • These findings demonstrate the critical role of CLCNKB in renal salt reabsorption and blood-pressure homeostasis, and demonstrate the potential role of specific CLCNKB antagonists as diuretic antihypertensive agents [35].
  • Here we report that disruption of the GC-A gene results in chronic elevations of blood pressure in mice on a normal salt diet [36].
  • The use of NEP antagonists as candidate drugs in cardiovascular disease is suggested by the blood pressure data reported herein [37].
  • Furthermore, P2rx4(-/-) mice have higher blood pressure and excrete smaller amounts of NO products in their urine than do wild-type mice [38].
  • Protocol violations were reported for 127 patients (32.6%), and included treatment with tPA more than 3 hours after symptom onset in 13.4%, treatment with anticoagulants within 24 hours of tPA administration in 9.3%, and tPA administration despite systolic blood pressure exceeding 185 mm Hg in 6.7% [39].

Analytical, diagnostic and therapeutic context of Blood Pressure


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  2. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II). Swedberg, K., Held, P., Kjekshus, J., Rasmussen, K., Rydén, L., Wedel, H. N. Engl. J. Med. (1992) [Pubmed]
  3. Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. Hu, F.B., Stampfer, M.J., Manson, J.E., Grodstein, F., Colditz, G.A., Speizer, F.E., Willett, W.C. N. Engl. J. Med. (2000) [Pubmed]
  4. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. Schunkert, H., Hense, H.W., Holmer, S.R., Stender, M., Perz, S., Keil, U., Lorell, B.H., Riegger, G.A. N. Engl. J. Med. (1994) [Pubmed]
  5. Formation of bradykinin: a major contributor to the innate inflammatory response. Joseph, K., Kaplan, A.P. Adv. Immunol. (2005) [Pubmed]
  6. Cancer incidence by levels of cholesterol. Williams, R.R., Sorlie, P.D., Feinleib, M., McNamara, P.M., Kannel, W.B., Dawber, T.R. JAMA (1981) [Pubmed]
  7. Blood-pressure response to moderate sodium restriction and to potassium supplementation in mild essential hypertension. Richards, A.M., Nicholls, M.G., Espiner, E.A., Ikram, H., Maslowski, A.H., Hamilton, E.J., Wells, J.E. Lancet (1984) [Pubmed]
  8. Endocrine, cardiovascular, and behavioral effects of intravenous protirelin in patients with panic disorder. Stein, M.B., Uhde, T.W. Arch. Gen. Psychiatry (1991) [Pubmed]
  9. Diagnosis of erectile impotence in diabetes mellitus. An objective and specific method. Karacan, I. Ann. Intern. Med. (1980) [Pubmed]
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  11. Structure and function of CLCA proteins. Loewen, M.E., Forsyth, G.W. Physiol. Rev. (2005) [Pubmed]
  12. Neuroendocrine control of body fluid metabolism. Antunes-Rodrigues, J., de Castro, M., Elias, L.L., Valença, M.M., McCann, S.M. Physiol. Rev. (2004) [Pubmed]
  13. Angiotensin, thirst, and sodium appetite. Fitzsimons, J.T. Physiol. Rev. (1998) [Pubmed]
  14. Emilin1 links TGF-beta maturation to blood pressure homeostasis. Zacchigna, L., Vecchione, C., Notte, A., Cordenonsi, M., Dupont, S., Maretto, S., Cifelli, G., Ferrari, A., Maffei, A., Fabbro, C., Braghetta, P., Marino, G., Selvetella, G., Aretini, A., Colonnese, C., Bettarini, U., Russo, G., Soligo, S., Adorno, M., Bonaldo, P., Volpin, D., Piccolo, S., Lembo, G., Bressan, G.M. Cell (2006) [Pubmed]
  15. Accentuated vascular and endocrine response to SQ 20881 in hypertension. Williams, G.H., Hollenberg, N.K. N. Engl. J. Med. (1977) [Pubmed]
  16. The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension. Estacio, R.O., Jeffers, B.W., Hiatt, W.R., Biggerstaff, S.L., Gifford, N., Schrier, R.W. N. Engl. J. Med. (1998) [Pubmed]
  17. The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients. Tuck, M.L., Sowers, J., Dornfeld, L., Kledzik, G., Maxwell, M. N. Engl. J. Med. (1981) [Pubmed]
  18. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. Krum, H., Viskoper, R.J., Lacourciere, Y., Budde, M., Charlon, V. N. Engl. J. Med. (1998) [Pubmed]
  19. Sympathetic cardioneuropathy in dysautonomias. Goldstein, D.S., Holmes, C., Cannon, R.O., Eisenhofer, G., Kopin, I.J. N. Engl. J. Med. (1997) [Pubmed]
  20. Myocardial ischemia caused by distal coronary-artery constriction in stable angina pectoris. Pupita, G., Maseri, A., Kaski, J.C., Galassi, A.R., Gavrielides, S., Davies, G., Crea, F. N. Engl. J. Med. (1990) [Pubmed]
  21. A role for smad6 in development and homeostasis of the cardiovascular system. Galvin, K.M., Donovan, M.J., Lynch, C.A., Meyer, R.I., Paul, R.J., Lorenz, J.N., Fairchild-Huntress, V., Dixon, K.L., Dunmore, J.H., Gimbrone, M.A., Falb, D., Huszar, D. Nat. Genet. (2000) [Pubmed]
  22. Predicting diabetic nephropathy in insulin-dependent patients. Mogensen, C.E., Christensen, C.K. N. Engl. J. Med. (1984) [Pubmed]
  23. Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure. Ligtenberg, G., Blankestijn, P.J., Oey, P.L., Klein, I.H., Dijkhorst-Oei, L.T., Boomsma, F., Wieneke, G.H., van Huffelen, A.C., Koomans, H.A. N. Engl. J. Med. (1999) [Pubmed]
  24. Evidence of prostacyclin deficiency in the syndrome of hyporeninemic hypoaldosteronism. Nadler, J.L., Lee, F.O., Hsueh, W., Horton, R. N. Engl. J. Med. (1986) [Pubmed]
  25. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Tang, K.M., Wang, G.R., Lu, P., Karas, R.H., Aronovitz, M., Heximer, S.P., Kaltenbronn, K.M., Blumer, K.J., Siderovski, D.P., Zhu, Y., Mendelsohn, M.E., Tang, M., Wang, G. Nat. Med. (2003) [Pubmed]
  26. Identification of receptors for neuromedin U and its role in feeding. Howard, A.D., Wang, R., Pong, S.S., Mellin, T.N., Strack, A., Guan, X.M., Zeng, Z., Williams, D.L., Feighner, S.D., Nunes, C.N., Murphy, B., Stair, J.N., Yu, H., Jiang, Q., Clements, M.K., Tan, C.P., McKee, K.K., Hreniuk, D.L., McDonald, T.P., Lynch, K.R., Evans, J.F., Austin, C.P., Caskey, C.T., Van der Ploeg, L.H., Liu, Q. Nature (2000) [Pubmed]
  27. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. Graham, I.M., Daly, L.E., Refsum, H.M., Robinson, K., Brattström, L.E., Ueland, P.M., Palma-Reis, R.J., Boers, G.H., Sheahan, R.G., Israelsson, B., Uiterwaal, C.S., Meleady, R., McMaster, D., Verhoef, P., Witteman, J., Rubba, P., Bellet, H., Wautrecht, J.C., de Valk, H.W., Sales Lúis, A.C., Parrot-Rouland, F.M., Tan, K.S., Higgins, I., Garcon, D., Andria, G. JAMA (1997) [Pubmed]
  28. Effects of intranasal cocaine on sympathetic nerve discharge in humans. Jacobsen, T.N., Grayburn, P.A., Snyder, R.W., Hansen, J., Chavoshan, B., Landau, C., Lange, R.A., Hillis, L.D., Victor, R.G. J. Clin. Invest. (1997) [Pubmed]
  29. Reflex increase in blood pressure during the intracoronary administration of adenosine in man. Cox, D.A., Vita, J.A., Treasure, C.B., Fish, R.D., Selwyn, A.P., Ganz, P. J. Clin. Invest. (1989) [Pubmed]
  30. Fibrinogen as a risk factor for stroke and myocardial infarction. Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., Tibblin, G. N. Engl. J. Med. (1984) [Pubmed]
  31. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. Mogensen, C.E. N. Engl. J. Med. (1984) [Pubmed]
  32. Deficient sympathetic nervous response in familial dysautonomia. Ziegler, M.G., Lake, C.R., Kopin, I.J. N. Engl. J. Med. (1976) [Pubmed]
  33. Comparison of captopril and enalapril in patients with severe chronic heart failure. Packer, M., Lee, W.H., Yushak, M., Medina, N. N. Engl. J. Med. (1986) [Pubmed]
  34. Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia. Kaplan, N.M., Carnegie, A., Raskin, P., Heller, J.A., Simmons, M. N. Engl. J. Med. (1985) [Pubmed]
  35. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Simon, D.B., Bindra, R.S., Mansfield, T.A., Nelson-Williams, C., Mendonca, E., Stone, R., Schurman, S., Nayir, A., Alpay, H., Bakkaloglu, A., Rodriguez-Soriano, J., Morales, J.M., Sanjad, S.A., Taylor, C.M., Pilz, D., Brem, A., Trachtman, H., Griswold, W., Richard, G.A., John, E., Lifton, R.P. Nat. Genet. (1997) [Pubmed]
  36. Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide. Lopez, M.J., Wong, S.K., Kishimoto, I., Dubois, S., Mach, V., Friesen, J., Garbers, D.L., Beuve, A. Nature (1995) [Pubmed]
  37. The control of microvascular permeability and blood pressure by neutral endopeptidase. Lu, B., Figini, M., Emanueli, C., Geppetti, P., Grady, E.F., Gerard, N.P., Ansell, J., Payan, D.G., Gerard, C., Bunnett, N. Nat. Med. (1997) [Pubmed]
  38. Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Yamamoto, K., Sokabe, T., Matsumoto, T., Yoshimura, K., Shibata, M., Ohura, N., Fukuda, T., Sato, T., Sekine, K., Kato, S., Isshiki, M., Fujita, T., Kobayashi, M., Kawamura, K., Masuda, H., Kamiya, A., Ando, J. Nat. Med. (2006) [Pubmed]
  39. Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study. Albers, G.W., Bates, V.E., Clark, W.M., Bell, R., Verro, P., Hamilton, S.A. JAMA (2000) [Pubmed]
  40. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. Nolan, J.J., Ludvik, B., Beerdsen, P., Joyce, M., Olefsky, J. N. Engl. J. Med. (1994) [Pubmed]
  41. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Materson, B.J., Reda, D.J., Cushman, W.C., Massie, B.M., Freis, E.D., Kochar, M.S., Hamburger, R.J., Fye, C., Lakshman, R., Gottdiener, J. N. Engl. J. Med. (1993) [Pubmed]
  42. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. Perl, T.M., Bédard, L., Kosatsky, T., Hockin, J.C., Todd, E.C., Remis, R.S. N. Engl. J. Med. (1990) [Pubmed]
  43. Pancreas transplantation: indications and consequences. Larsen, J.L. Endocr. Rev. (2004) [Pubmed]
  44. Distribution of and factors associated with serum homocysteine levels in children: Child and Adolescent Trial for Cardiovascular Health. Osganian, S.K., Stampfer, M.J., Spiegelman, D., Rimm, E., Cutler, J.A., Feldman, H.A., Montgomery, D.H., Webber, L.S., Lytle, L.A., Bausserman, L., Nader, P.R. JAMA (1999) [Pubmed]
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