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Walitza, S. et al.

Susanne Walitza, André Scherag, Tobias J. Renner, Anke Hinney, Helmut Remschmidt, Beate Herpertz-Dahlmann, Eberhard Schulz, Helmut Schafer, Klaus W. Lange, Christoph Wewetzer, Manfred Gerlach,

Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system.

The dopaminergic system has been shown to be involved in the aetiology of obsessive-compulsive disorder (OCD). Family studies suggest a higher genetic loading in patients with early onset OCD. Our investigation is the first family-based association study concerning polymorphisms in genes of the dopaminergic system in early onset OCD. We studied polymorphisms within the dopamine-4 receptor gene (DRD4), the dopamine transporter gene (DAT1) and the catecholamine-O-methyltransferase gene (COMT). Associations of alleles of DRD4 and COMT with OCD have previously been reported in adults, while a trend towards an association was found for DAT1 alleles. In our study we observed transmission disequilibrium for the 48-bp repeat polymorphism of the DRD4 gene using the ETDT (P=0.047) in 69 trios comprising patients with early onset OCD and both of their parents. Post hoc TDT analysis of the DRD4 showed reduced transmission of the 4-repeat allele and a slightly increased transmission rate for the 7- and the 2-repeat allele. No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group.[1]

References

Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. Walitza, S., Scherag, A., Renner, T.J., Hinney, A., Remschmidt, H., Herpertz-Dahlmann, B., Schulz, E., Schafer, H., Lange, K.W., Wewetzer, C., Gerlach, M. J. Neural. Transm (2008) [Pubmed]

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