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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.

Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.[1]

References

  1. A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce. Delgado, R., Hidalgo, P., Diaz, F., Latorre, R., Labarca, P. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
 
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