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Chemical Compound Review

1,4,5-Insp3     [(1R,2S,3R,4R,5S,6R)-2,4,5- trihydroxy-3,6...

Synonyms: InsP3, CHEMBL279107, CHEBI:16595, HMDB01498, CMC_6811, ...
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Disease relevance of inositol 1,4,5-trisphosphate


Psychiatry related information on inositol 1,4,5-trisphosphate


High impact information on inositol 1,4,5-trisphosphate


Chemical compound and disease context of inositol 1,4,5-trisphosphate


Biological context of inositol 1,4,5-trisphosphate


Anatomical context of inositol 1,4,5-trisphosphate


Associations of inositol 1,4,5-trisphosphate with other chemical compounds


Gene context of inositol 1,4,5-trisphosphate

  • N-WASP is tightly regulated by multiple signals: Only costimulation by Cdc42 and phosphatidylinositol (4,5)-bisphosphate (PIP2) yields potent polymerization [33].
  • We report here that this Rac1-dependent pathway involves recruitment of phosphoinositol-4-phosphate-5-kinase (PIP5K) to form phosphoinositol-4,5-bisphosphate (PIP2) at the phagocytic cup [34].
  • The results suggest that Ca2+ influx prevents PIP2 depletion by inhibiting PLC activity and facilitating PIP2 recycling [35].
  • Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors [35].
  • Two independent mutations in the PIP2 recycling pathway (rdgB and cds) prevented recovery from inactivation [35].

Analytical, diagnostic and therapeutic context of inositol 1,4,5-trisphosphate


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  2. HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. Manninen, A., Saksela, K. J. Exp. Med. (2002) [Pubmed]
  3. Effect of thrombin on calcium homeostasis in chick embryonic heart cells. Receptor-operated calcium entry with inositol trisphosphate and a pertussis toxin-sensitive G protein as second messengers. Chien, W.W., Mohabir, R., Clusin, W.T. J. Clin. Invest. (1990) [Pubmed]
  4. Enhanced inositol trisphosphate response to alpha 1-adrenergic stimulation in cardiac myocytes exposed to hypoxia. Heathers, G.P., Evers, A.S., Corr, P.B. J. Clin. Invest. (1989) [Pubmed]
  5. Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis. Powers, R.E., Saluja, A.K., Houlihan, M.J., Steer, M.L. J. Clin. Invest. (1986) [Pubmed]
  6. Intracellular inositol (1,4,5)-trisphosphate receptor levels are preserved in Alzheimer's disease platelets. Garlind, A., Wiehager, B., Winblad, B., Fowler, C.J. Neurobiol. Aging (1997) [Pubmed]
  7. Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study. Soares, J.C., Mallinger, A.G., Dippold, C.S., Forster Wells, K., Frank, E., Kupfer, D.J. Psychopharmacology (Berl.) (2000) [Pubmed]
  8. Electroconvulsive shock stimulates polyphosphoinositide degradation and inositol trisphosphate accumulation in rat cerebrum: lithium pretreatment does not potentiate these changes. Vadnal, R.E., Bazan, N.G. Neurosci. Lett. (1987) [Pubmed]
  9. Morituri te salutant? Olfactory signal transduction and the role of phosphoinositides. Elsaesser, R., Paysan, J. J. Neurocytol. (2005) [Pubmed]
  10. Inositol trisphosphate and diacylglycerol: two interacting second messengers. Berridge, M.J. Annu. Rev. Biochem. (1987) [Pubmed]
  11. Plasma membrane channels formed by connexins: their regulation and functions. Saez, J.C., Berthoud, V.M., Branes, M.C., Martinez, A.D., Beyer, E.C. Physiol. Rev. (2003) [Pubmed]
  12. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Kagan, J.C., Medzhitov, R. Cell (2006) [Pubmed]
  13. PIP2 and PIP3: complex roles at the cell surface. Czech, M.P. Cell (2000) [Pubmed]
  14. Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J.D., Sheetz, M.P., Meyer, T. Cell (2000) [Pubmed]
  15. Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Wenk, M.R., Lucast, L., Di Paolo, G., Romanelli, A.J., Suchy, S.F., Nussbaum, R.L., Cline, G.W., Shulman, G.I., McMurray, W., De Camilli, P. Nat. Biotechnol. (2003) [Pubmed]
  16. Enhanced phosphodiesteratic breakdown and turnover of phosphoinositides during reperfusion of ischemic rat heart. Otani, H., Prasad, M.R., Engelman, R.M., Otani, H., Cordis, G.A., Das, D.K. Circ. Res. (1988) [Pubmed]
  17. Pertussis toxin can activate human platelets. Comparative effects of holotoxin and its ADP-ribosylating S1 subunit. Banga, H.S., Walker, R.K., Winberry, L.K., Rittenhouse, S.E. J. Biol. Chem. (1987) [Pubmed]
  18. Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. Smith, C.D., Lane, B.C., Kusaka, I., Verghese, M.W., Snyderman, R. J. Biol. Chem. (1985) [Pubmed]
  19. An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling. Thomas, G.M., Cunningham, E., Fensome, A., Ball, A., Totty, N.F., Truong, O., Hsuan, J.J., Cockcroft, S. Cell (1993) [Pubmed]
  20. An early decrease in phosphatidylinositol turnover occurs on induction of Friend cell differentiation and precedes the decrease in c-myc expression. Faletto, D.L., Arrow, A.S., Macara, I.G. Cell (1985) [Pubmed]
  21. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Zhao, K., Wang, W., Rando, O.J., Xue, Y., Swiderek, K., Kuo, A., Crabtree, G.R. Cell (1998) [Pubmed]
  22. ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Bretscher, A., Chambers, D., Nguyen, R., Reczek, D. Annu. Rev. Cell Dev. Biol. (2000) [Pubmed]
  23. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Carney, D.H., Scott, D.L., Gordon, E.A., LaBelle, E.F. Cell (1985) [Pubmed]
  24. Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles. Ferris, C.D., Huganir, R.L., Supattapone, S., Snyder, S.H. Nature (1989) [Pubmed]
  25. Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle. Volpe, P., Salviati, G., Di Virgilio, F., Pozzan, T. Nature (1985) [Pubmed]
  26. Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Bezprozvanny, I., Watras, J., Ehrlich, B.E. Nature (1991) [Pubmed]
  27. The inositol trisphosphate calcium channel is inactivated by inositol trisphosphate. Hajnóczky, G., Thomas, A.P. Nature (1994) [Pubmed]
  28. Cellular mechanisms of melatonin action. Vanecek, J. Physiol. Rev. (1998) [Pubmed]
  29. A saturable receptor for 32P-inositol-1,4,5-triphosphate in hepatocytes and neutrophils. Spät, A., Bradford, P.G., McKinney, J.S., Rubin, R.P., Putney, J.W. Nature (1986) [Pubmed]
  30. Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor. Mignery, G.A., Südhof, T.C., Takei, K., De Camilli, P. Nature (1989) [Pubmed]
  31. Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels. Ciapa, B., Pesando, D., Wilding, M., Whitaker, M. Nature (1994) [Pubmed]
  32. Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma. Sussman, J.J., Merćep, M., Saito, T., Germain, R.N., Bonvini, E., Ashwell, J.D. Nature (1988) [Pubmed]
  33. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Prehoda, K.E., Scott, J.A., Mullins, R.D., Lim, W.A. Science (2000) [Pubmed]
  34. Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. Wong, K.W., Isberg, R.R. J. Exp. Med. (2003) [Pubmed]
  35. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Hardie, R.C., Raghu, P., Moore, S., Juusola, M., Baines, R.A., Sweeney, S.T. Neuron (2001) [Pubmed]
  36. Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2. Matuoka, K., Fukami, K., Nakanishi, O., Kawai, S., Takenawa, T. Science (1988) [Pubmed]
  37. Identification of a suppressor of the Dictyostelium profilin-minus phenotype as a CD36/LIMP-II homologue. Karakesisoglou, I., Janssen, K.P., Eichinger, L., Noegel, A.A., Schleicher, M. J. Cell Biol. (1999) [Pubmed]
  38. Regulation of presynaptic phosphatidylinositol 4,5-biphosphate by neuronal activity. Micheva, K.D., Holz, R.W., Smith, S.J. J. Cell Biol. (2001) [Pubmed]
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