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Chemical Compound Review

1,4,5-Insp3     [(1R,2S,3R,4R,5S,6R)-2,4,5- trihydroxy-3,6...

Synonyms: InsP3, CHEMBL279107, CHEBI:16595, HMDB01498, CMC_6811, ...
 
 
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Disease relevance of inositol 1,4,5-trisphosphate

 

Psychiatry related information on inositol 1,4,5-trisphosphate

 

High impact information on inositol 1,4,5-trisphosphate

 

Chemical compound and disease context of inositol 1,4,5-trisphosphate

 

Biological context of inositol 1,4,5-trisphosphate

 

Anatomical context of inositol 1,4,5-trisphosphate

 

Associations of inositol 1,4,5-trisphosphate with other chemical compounds

 

Gene context of inositol 1,4,5-trisphosphate

  • N-WASP is tightly regulated by multiple signals: Only costimulation by Cdc42 and phosphatidylinositol (4,5)-bisphosphate (PIP2) yields potent polymerization [33].
  • We report here that this Rac1-dependent pathway involves recruitment of phosphoinositol-4-phosphate-5-kinase (PIP5K) to form phosphoinositol-4,5-bisphosphate (PIP2) at the phagocytic cup [34].
  • The results suggest that Ca2+ influx prevents PIP2 depletion by inhibiting PLC activity and facilitating PIP2 recycling [35].
  • Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors [35].
  • Two independent mutations in the PIP2 recycling pathway (rdgB and cds) prevented recovery from inactivation [35].
 

Analytical, diagnostic and therapeutic context of inositol 1,4,5-trisphosphate

References

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