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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Murphy, J.V.

Neurochemical changes in Leigh's disease.

A series of children with Leigh's disease had normal hepatic pyruvate carboxylase activity, increased cerebral thiamine diphosphate, and decreased cerebral thiamine triphosphate. These thiamine esters were normal in liver. The author suggests that the histologic changes of Leigh's disease, as well as the similar changes of Wernicke's disease, could be due to a deficiency of cerebral thiamine triphosphate.[1]

References

Neurochemical changes in Leigh's disease. Murphy, J.V. J. Nutr. Sci. Vitaminol. (1976) [Pubmed]

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