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Chemical Compound Review

Diphosphat     dioxido-oxo-phosphonatooxy- phosphorane

Synonyms: diphosphate, Pyrophosphat, AG-D-80433, CHEBI:16838, CHEBI:18361, ...
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Disease relevance of dioxido-oxo-phosphonatooxy-phosphorane


Psychiatry related information on dioxido-oxo-phosphonatooxy-phosphorane

  • Our data suggest that an inborn error (i.e., high Km of transketolase for thiamine pyrophosphate) predisposing to thiamine deficiency diseases similar to those reported in Wernicke-Korsakoff syndrome may occur in the general population [6].
  • Primary and secondary kinetic isotope effects indicate that this ribozyme stabilizes a highly dissociative reaction with considerable sp2 hybridization and negligible bond order between the departing pyrophosphate leaving group and the anomeric carbon [7].
  • Changes in the level of free Mg(2+) ions, which are within the physiological range, are shown to modulate the motor activity of myosin-IE by inhibiting the release of adenosine diphosphate [8].
  • BACKGROUND: Infant cereals are commonly fortified with insoluble iron compounds with low relative bioavailability, such as ferric pyrophosphate, because of organoleptic changes that occur after addition of water-soluble iron sources [9].
  • Compared to the older method for the preparation of cytidine diphosphate diglyceride and analogs thereof, the new method has several advantages: reaction times are reduced from several days to several hours and the yield of the reactions is generally increased from 20-40% to between 50 and 80% [10].

High impact information on dioxido-oxo-phosphonatooxy-phosphorane


Chemical compound and disease context of dioxido-oxo-phosphonatooxy-phosphorane


Biological context of dioxido-oxo-phosphonatooxy-phosphorane


Anatomical context of dioxido-oxo-phosphonatooxy-phosphorane


Associations of dioxido-oxo-phosphonatooxy-phosphorane with other chemical compounds


Gene context of dioxido-oxo-phosphonatooxy-phosphorane

  • Alternatively, because accumulation of unhydrolyzed pyrophosphate during nucleotide incorporation inhibits polymerization, NURF may also have been adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite [36].
  • Although COPII vesicle budding is promoted by GTP or a nonhydrolyzable analogue, guanylimide diphosphate (GMP-PNP), Sec16p stimulation is dependent on GTP in the reaction [37].
  • These results suggest that direct or indirect interaction of Dcp1p with Dcp2p is required for the production of active decapping enzyme, perhaps in a process requiring the hydrolysis of a pyrophosphate bond [38].
  • ANKH encodes a putative transmembrane inorganic pyrophosphate (PPi) transport channel [39].
  • The mouse cells lacked HPRT and were also deficient in adenine phosphoribosyltransferase (APRT; AMP: pyrophosphate phosphoribosyltransferase; EC2.4.2.7) [40].

Analytical, diagnostic and therapeutic context of dioxido-oxo-phosphonatooxy-phosphorane


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