The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Diphosphat     dioxido-oxo-phosphonatooxy- phosphorane

Synonyms: diphosphate, Pyrophosphat, AG-D-80433, CHEBI:16838, CHEBI:18361, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of dioxido-oxo-phosphonatooxy-phosphorane

 

Psychiatry related information on dioxido-oxo-phosphonatooxy-phosphorane

  • Our data suggest that an inborn error (i.e., high Km of transketolase for thiamine pyrophosphate) predisposing to thiamine deficiency diseases similar to those reported in Wernicke-Korsakoff syndrome may occur in the general population [6].
  • Primary and secondary kinetic isotope effects indicate that this ribozyme stabilizes a highly dissociative reaction with considerable sp2 hybridization and negligible bond order between the departing pyrophosphate leaving group and the anomeric carbon [7].
  • Changes in the level of free Mg(2+) ions, which are within the physiological range, are shown to modulate the motor activity of myosin-IE by inhibiting the release of adenosine diphosphate [8].
  • BACKGROUND: Infant cereals are commonly fortified with insoluble iron compounds with low relative bioavailability, such as ferric pyrophosphate, because of organoleptic changes that occur after addition of water-soluble iron sources [9].
  • Compared to the older method for the preparation of cytidine diphosphate diglyceride and analogs thereof, the new method has several advantages: reaction times are reduced from several days to several hours and the yield of the reactions is generally increased from 20-40% to between 50 and 80% [10].
 

High impact information on dioxido-oxo-phosphonatooxy-phosphorane

 

Chemical compound and disease context of dioxido-oxo-phosphonatooxy-phosphorane

 

Biological context of dioxido-oxo-phosphonatooxy-phosphorane

 

Anatomical context of dioxido-oxo-phosphonatooxy-phosphorane

 

Associations of dioxido-oxo-phosphonatooxy-phosphorane with other chemical compounds

 

Gene context of dioxido-oxo-phosphonatooxy-phosphorane

  • Alternatively, because accumulation of unhydrolyzed pyrophosphate during nucleotide incorporation inhibits polymerization, NURF may also have been adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite [36].
  • Although COPII vesicle budding is promoted by GTP or a nonhydrolyzable analogue, guanylimide diphosphate (GMP-PNP), Sec16p stimulation is dependent on GTP in the reaction [37].
  • These results suggest that direct or indirect interaction of Dcp1p with Dcp2p is required for the production of active decapping enzyme, perhaps in a process requiring the hydrolysis of a pyrophosphate bond [38].
  • ANKH encodes a putative transmembrane inorganic pyrophosphate (PPi) transport channel [39].
  • The mouse cells lacked HPRT and were also deficient in adenine phosphoribosyltransferase (APRT; AMP: pyrophosphate phosphoribosyltransferase; EC2.4.2.7) [40].
 

Analytical, diagnostic and therapeutic context of dioxido-oxo-phosphonatooxy-phosphorane

References

  1. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Fan, Z., Beresford, P.J., Oh, D.Y., Zhang, D., Lieberman, J. Cell (2003) [Pubmed]
  2. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nürnberg, P., Thiele, H., Chandler, D., Höhne, W., Cunningham, M.L., Ritter, H., Leschik, G., Uhlmann, K., Mischung, C., Harrop, K., Goldblatt, J., Borochowitz, Z.U., Kotzot, D., Westermann, F., Mundlos, S., Braun, H.S., Laing, N., Tinschert, S. Nat. Genet. (2001) [Pubmed]
  3. The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Yin, Y.W., Steitz, T.A. Cell (2004) [Pubmed]
  4. Characterization of the 5' termini of hn RNA in mouse L cells: implications for processing and cap formation. Schibler, U., Perry, R.P. Cell (1976) [Pubmed]
  5. Site-specific mutagenesis of AIDS virus reverse transcriptase. Larder, B.A., Purifoy, D.J., Powell, K.L., Darby, G. Nature (1987) [Pubmed]
  6. Transketolase abnormality in cultured fibroblasts from familial chronic alcoholic men and their male offspring. Mukherjee, A.B., Svoronos, S., Ghazanfari, A., Martin, P.R., Fisher, A., Roecklein, B., Rodbard, D., Staton, R., Behar, D., Berg, C.J. J. Clin. Invest. (1987) [Pubmed]
  7. An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects. Unrau, P.J., Bartel, D.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis. Dürrwang, U., Fujita-Becker, S., Erent, M., Kull, F.J., Tsiavaliaris, G., Geeves, M.A., Manstein, D.J. J. Cell. Sci. (2006) [Pubmed]
  9. Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate. Davidsson, L., Kastenmayer, P., Szajewska, H., Hurrell, R.F., Barclay, D. Am. J. Clin. Nutr. (2000) [Pubmed]
  10. Antiviral nucleoside diphosphate diglycerides: improved synthesis and facilitated purification. van Wijk, G.M., Hostetler, K.Y., van den Bosch, H. J. Lipid Res. (1992) [Pubmed]
  11. Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]. Hogg, T., Mechold, U., Malke, H., Cashel, M., Hilgenfeld, R. Cell (2004) [Pubmed]
  12. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Rutsch, F., Ruf, N., Vaingankar, S., Toliat, M.R., Suk, A., Höhne, W., Schauer, G., Lehmann, M., Roscioli, T., Schnabel, D., Epplen, J.T., Knisely, A., Superti-Furga, A., McGill, J., Filippone, M., Sinaiko, A.R., Vallance, H., Hinrichs, B., Smith, W., Ferre, M., Terkeltaub, R., Nürnberg, P. Nat. Genet. (2003) [Pubmed]
  13. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Okawa, A., Nakamura, I., Goto, S., Moriya, H., Nakamura, Y., Ikegawa, S. Nat. Genet. (1998) [Pubmed]
  14. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. Lüscher, T.F., Diederich, D., Siebenmann, R., Lehmann, K., Stulz, P., von Segesser, L., Yang, Z.H., Turina, M., Grädel, E., Weber, E. N. Engl. J. Med. (1988) [Pubmed]
  15. Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei. Noguchi, H., Prem veer Reddy, G., Pardee, A.B. Cell (1983) [Pubmed]
  16. Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Lochrie, M.A., Hurley, J.B., Simon, M.I. Science (1985) [Pubmed]
  17. Ectopic production of guanosine penta- and tetraphosphate can initiate early developmental gene expression in Myxococcus xanthus. Singer, M., Kaiser, D. Genes Dev. (1995) [Pubmed]
  18. Scintigraphic evaluation of suspected acute myocardial infarction. Kan, M.K., Hopkins, G.B., Carroll, C.F. JAMA (1977) [Pubmed]
  19. Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes. Berger, N.A., Adams, J.W., Sikorski, G.W., Petzold, S.J., Shearer, W.T. J. Clin. Invest. (1978) [Pubmed]
  20. Crystal-induced neutrophil activation. III. Inflammatory microcrystals induce a distinct pattern of tyrosine phosphorylation in human neutrophils. Gaudry, M., Roberge, C.J., de Médicis, R., Lussier, A., Poubelle, P.E., Naccache, P.H. J. Clin. Invest. (1993) [Pubmed]
  21. Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts. Olden, K., Pratt, R.M., Yamada, K.M. Cell (1978) [Pubmed]
  22. Sequence specificity of trinucleoside diphosphate binding to polymerized tobacco mosaic virus protein. Steckert, J.J., Schuster, T.M. Nature (1982) [Pubmed]
  23. Cloned fragment A of diphtheria toxin is expressed and secreted into the periplasmic space of Escherichia coli K12. Leong, D., Coleman, K.D., Murphy, J.R. Science (1983) [Pubmed]
  24. Molecular basis for interactions of G protein betagamma subunits with effectors. Ford, C.E., Skiba, N.P., Bae, H., Daaka, Y., Reuveny, E., Shekter, L.R., Rosal, R., Weng, G., Yang, C.S., Iyengar, R., Miller, R.J., Jan, L.Y., Lefkowitz, R.J., Hamm, H.E. Science (1998) [Pubmed]
  25. Variable occurrence of the nrdB intron in the T-even phages suggests intron mobility. Pedersen-Lane, J., Belfort, M. Science (1987) [Pubmed]
  26. Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. Blass, J.P., Gibson, G.E. N. Engl. J. Med. (1977) [Pubmed]
  27. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. Tanaka, Y., Morita, C.T., Tanaka, Y., Nieves, E., Brenner, M.B., Bloom, B.R. Nature (1995) [Pubmed]
  28. Assembly of microtubules from nucleotide-depleted tubulin. Bayley, P.M., Manser, E.J. Nature (1985) [Pubmed]
  29. Cellular applications of 31P and 13C nuclear magnetic resonance. Shulman, R.G., Brown, T.R., Ugurbil, K., Ogawa, S., Cohen, S.M., den Hollander, J.A. Science (1979) [Pubmed]
  30. Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor. Steinberg, S.F., Drugge, E.D., Bilezikian, J.P., Robinson, R.B. Science (1985) [Pubmed]
  31. Specific inhibition of ribosomal RNA synthesis in vitro by guanosine 3' diphosphate, 5' diphosphate. van Ooyen, A.J., de Boer, H.A., Ab, G., Gruber, M. Nature (1975) [Pubmed]
  32. Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats. Matas, A.J., Sutherland, D.E., Steffes, M.W., Mauer, S.M., Sowe, A., Simmons, R.L., Najarian, J.S. Science (1976) [Pubmed]
  33. Elevated creatine kinase MB isoenzyme levels in marathon runners. Normal myocardial scintigrams suggest noncardiac source. Siegel, A.J., Silverman, L.M., Holman, B.L. JAMA (1981) [Pubmed]
  34. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. Mellor, E.A., Austen, K.F., Boyce, J.A. J. Exp. Med. (2002) [Pubmed]
  35. Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. Zhang, Y.Y., Vik, T.A., Ryder, J.W., Srour, E.F., Jacks, T., Shannon, K., Clapp, D.W. J. Exp. Med. (1998) [Pubmed]
  36. Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Gdula, D.A., Sandaltzopoulos, R., Tsukiyama, T., Ossipow, V., Wu, C. Genes Dev. (1998) [Pubmed]
  37. Sec16p potentiates the action of COPII proteins to bud transport vesicles. Supek, F., Madden, D.T., Hamamoto, S., Orci, L., Schekman, R. J. Cell Biol. (2002) [Pubmed]
  38. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. Dunckley, T., Parker, R. EMBO J. (1999) [Pubmed]
  39. Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH. Williams, C.J., Zhang, Y., Timms, A., Bonavita, G., Caeiro, F., Broxholme, J., Cuthbertson, J., Jones, Y., Marchegiani, R., Reginato, A., Russell, R.G., Wordsworth, B.P., Carr, A.J., Brown, M.A. Am. J. Hum. Genet. (2002) [Pubmed]
  40. Localized Derepression on the Human Inactive X Chromosone in Mouse-Human Cell Hybrids. Kahan, B., DeMars, R. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  41. Fructose 1-6 diphosphate prevents intestinal ischemic reperfusion injury and death in rats. Sun, J.X., Farias, L.A., Markov, A.K. Gastroenterology (1990) [Pubmed]
  42. Coalescence of microsomal vesicles from rat liver: a phenomenon occurring in parallel with enhancement of the glycosylation activity during incubation of stripped rough microsomes with GTP. Paiement, J., Beaufay, H., Godelaine, D. J. Cell Biol. (1980) [Pubmed]
  43. Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography. la Cour, T.F., Nyborg, J., Thirup, S., Clark, B.F. EMBO J. (1985) [Pubmed]
  44. Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source. Larca, L.J., Coppola, J.T., Honig, S. Ann. Intern. Med. (1981) [Pubmed]
  45. Calcium oxalate microcrystalline-associated arthritis in end-stage renal disease. Hoffman, G.S., Schumacher, H.R., Paul, H., Cherian, V., Reed, R., Ramsay, A.G., Franck, W.A. Ann. Intern. Med. (1982) [Pubmed]
 
WikiGenes - Universities