Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

van de Kraats, J. et al.

Jan van de Kraats, Martijn J. Kanis, Stijn W. Genders, Dirk van Norren,

Lutein and zeaxanthin measured separately in the living human retina with fundus reflectometry.

PURPOSE: To separately measure the optical densities of lutein (L) and zeaxanthin (Z) in the human retina in vivo. L and Z are the basic constituents of the macular pigment (MP). METHODS: Spectral fundus reflectance was measured in 23 subjects (group 1) at 0 degrees , 1 degrees , 2 degrees , 4 degrees , and 8 degrees eccentricity with a modified macular pigment reflectometer. A model generated the optical densities of L (LOD) and Z (ZOD), using their slightly different absorption spectra. Three other subjects (group 2) took 20 mg/d zeaxanthin for 6 months; they were measured approximately monthly for 18 months. RESULTS: Mean LOD for group 1 at the central fovea was 0.200 +/- 0.061 (range, 0.085-0.305), mean ZOD was 0.494 +/- 0.169 (range, 0.169-0.806), resulting in a mean Z fraction [ZOD/(LOD + ZOD)] of 0.71. ZOD dropped faster toward the periphery than LOD, measuring 0.044 and 0.010 (Z fraction 0.18) at 8 degrees , respectively. Zeaxanthin supplementation in group 2 caused a significant increase in ZOD, and no or minor changes in LOD. ZOD further increased over a 10-month period after supplementation in all subjects. CONCLUSIONS: LOD and ZOD had different spatial profiles that, apart from scaling factors, showed similarity to in vitro literature data. Supplementation with Z caused LOD to decrease and ZOD to increase. These results strongly suggest that the optical densities of L and Z can be assessed in vivo by fundus reflectometry, opening new ways of investigating the putative protective roles of L and Z in retinal disease.[1]

References

Lutein and zeaxanthin measured separately in the living human retina with fundus reflectometry. van de Kraats, J., Kanis, M.J., Genders, S.W., van Norren, D. Invest. Ophthalmol. Vis. Sci. (2008) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.