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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Retinal Diseases

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Disease relevance of Retinal Diseases


High impact information on Retinal Diseases


Chemical compound and disease context of Retinal Diseases

  • Cosegregation of RP with gln64-to-ter, gly106-to-arg, arg135-to-gly, cys140-to-ser, gly188-to-glu, his211-to-arg, and the splice site guanosine-to-thymidine indicates that these mutations are likely to cause retinal disease [11].
  • Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction [12].
  • PURPOSE: Low concentrations of excitotoxic agents such as glutamate decrease survival of retinal ganglion cells (RGCs) and may be an important cause of RGC death in a variety of retinal diseases [13].
  • Recordings of the ERC from normal and mutant mice may provide a useful tool for the analysis of models of retinal disease, as well as exploration of the molecular origin of light-activated Ca(2+) release [14].
  • We suggest that the rat urethane retinopathy models the plasticity of BRB components--RPE and endothelia--over the course of retinal disease [15].

Biological context of Retinal Diseases


Anatomical context of Retinal Diseases


Gene context of Retinal Diseases


Analytical, diagnostic and therapeutic context of Retinal Diseases


  1. Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells. Chen, F., Figueroa, D.J., Marmorstein, A.D., Zhang, Q., Petrukhin, K., Caskey, C.T., Austin, C.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Kameya, S., Hawes, N.L., Chang, B., Heckenlively, J.R., Naggert, J.K., Nishina, P.M. Hum. Mol. Genet. (2002) [Pubmed]
  3. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Forsythe, J.A., Jiang, B.H., Iyer, N.V., Agani, F., Leung, S.W., Koos, R.D., Semenza, G.L. Mol. Cell. Biol. (1996) [Pubmed]
  4. Unusual thermal and conformational properties of the rhodopsin congenital night blindness mutant Thr-94 --> Ile. Ramon, E., del Valle, L.J., Garriga, P. J. Biol. Chem. (2003) [Pubmed]
  5. Relationship between retinal and glomerular lesions in IDDM patients. Chavers, B.M., Mauer, S.M., Ramsay, R.C., Steffes, M.W. Diabetes (1994) [Pubmed]
  6. Identification and characterization of rod-derived cone viability factor. Léveillard, T., Mohand-Saïd, S., Lorentz, O., Hicks, D., Fintz, A.C., Clérin, E., Simonutti, M., Forster, V., Cavusoglu, N., Chalmel, F., Dollé, P., Poch, O., Lambrou, G., Sahel, J.A. Nat. Genet. (2004) [Pubmed]
  7. Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Humphries, M.M., Rancourt, D., Farrar, G.J., Kenna, P., Hazel, M., Bush, R.A., Sieving, P.A., Sheils, D.M., McNally, N., Creighton, P., Erven, A., Boros, A., Gulya, K., Capecchi, M.R., Humphries, P. Nat. Genet. (1997) [Pubmed]
  8. Gene regulation and differentiation in vertebrate ocular tissues. Kodama, R., Eguchi, G. Curr. Opin. Genet. Dev. (1994) [Pubmed]
  9. Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4). Deretic, D., Williams, A.H., Ransom, N., Morel, V., Hargrave, P.A., Arendt, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Simple and complex ABCR: genetic predisposition to retinal disease. Allikmets, R. Am. J. Hum. Genet. (2000) [Pubmed]
  11. Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin. Macke, J.P., Davenport, C.M., Jacobson, S.G., Hennessey, J.C., Gonzalez-Fernandez, F., Conway, B.P., Heckenlively, J., Palmer, R., Maumenee, I.H., Sieving, P. Am. J. Hum. Genet. (1993) [Pubmed]
  12. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. Gegg, M.E., Harry, R., Hankey, D., Zambarakji, H., Pryce, G., Baker, D., Adamson, P., Calder, V., Greenwood, J. J. Immunol. (2005) [Pubmed]
  13. Protective effect of arachidonic acid on glutamate neurotoxicity in rat retinal ganglion cells. Kawasaki, A., Han, M.H., Wei, J.Y., Hirata, K., Otori, Y., Barnstable, C.J. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  14. Early receptor current of wild-type and transducin knockout mice: photosensitivity and light-induced Ca2+ release. Woodruff, M.L., Lem, J., Fain, G.L. J. Physiol. (Lond.) (2004) [Pubmed]
  15. Urethane-induced rat retinopathy. Plasticity of the blood-retinal barrier in disease. Korte, G.E., Bellhorn, R.W., Burns, M.S. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  16. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev, S., Hernandez, J., Martinez, R., Chen, A., Plowman, G., Schlessinger, J. Mol. Cell. Biol. (1999) [Pubmed]
  17. Folding and subunit assembly of photoreceptor peripherin/rds is mediated by determinants within the extracellular/intradiskal EC2 domain: implications for heterogeneous molecular pathologies. Goldberg, A.F., Fales, L.M., Hurley, J.B., Khattree, N. J. Biol. Chem. (2001) [Pubmed]
  18. Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis. Engelbert, M., Gilmore, M.S. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  19. Cultured Müller cells have high levels of epidermal growth factor receptors. Roque, R.S., Caldwell, R.B., Behzadian, M.A. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  20. Gene expression profile of native human retinal pigment epithelium. Buraczynska, M., Mears, A.J., Zareparsi, S., Farjo, R., Filippova, E., Yuan, Y., MacNee, S.P., Hughes, B., Swaroop, A. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  21. Reliability and consistency of dark-adapted psychophysical measures in advanced eye disease. Kiser, A.K., Mladenovich, D., Eshraghi, F., Bourdeau, D., Dagnelie, G. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  22. Active scatter factor (HGF/SF) in proliferative vitreoretinal disease. Briggs, M.C., Grierson, I., Hiscott, P., Hunt, J.A. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  23. Targeting of the retinal pigment epithelium (RPE) by means of a rapidly scanned continuous wave (CW) laser beam. Brinkmann, R., Koop, N., Ozdemir, M., Alt, C., Schüle, G., Lin, C.P., Birngruber, R. Lasers in surgery and medicine. (2003) [Pubmed]
  24. Hypoxic regulation of vascular endothelial growth factor in retinal cells. Aiello, L.P., Northrup, J.M., Keyt, B.A., Takagi, H., Iwamoto, M.A. Arch. Ophthalmol. (1995) [Pubmed]
  25. Oxysterol-induced toxicity in R28 and ARPE-19 cells. Ong, J.M., Aoki, A.M., Seigel, G.M., Sacerio, I., Castellon, R., Nesburn, A.B., Kenney, M.C. Neurochem. Res. (2003) [Pubmed]
  26. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Aiello, L.P., Pierce, E.A., Foley, E.D., Takagi, H., Chen, H., Riddle, L., Ferrara, N., King, G.L., Smith, L.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  27. Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation. Bascom, R.A., Schappert, K., McInnes, R.R. Hum. Mol. Genet. (1993) [Pubmed]
  28. Localisation of a gene for central areolar choroidal dystrophy to chromosome 17p. Lotery, A.J., Ennis, K.T., Silvestri, G., Nicholl, S., McGibbon, D., Collins, A.D., Hughes, A.E. Hum. Mol. Genet. (1996) [Pubmed]
  29. CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Mehalow, A.K., Kameya, S., Smith, R.S., Hawes, N.L., Denegre, J.M., Young, J.A., Bechtold, L., Haider, N.B., Tepass, U., Heckenlively, J.R., Chang, B., Naggert, J.K., Nishina, P.M. Hum. Mol. Genet. (2003) [Pubmed]
  30. S-antigen is coded by [poly A+] mRNA from bovine retina. Altério, J., Dorey, C., Mirshahi, M., Faure, J.P., Barritault, D. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  31. A model of subretinal neovascularization in the pigmented rat. Frank, R.N., Das, A., Weber, M.L. Curr. Eye Res. (1989) [Pubmed]
  32. Efficacy of Prinomastat) (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization. Garcia, C., Bartsch, D.U., Rivero, M.E., Hagedorn, M., McDermott, C.D., Bergeron-Lynn, G., Cheng, L., Appelt, K., Freeman, W.R. Curr. Eye Res. (2002) [Pubmed]
  33. Transfection of basic fibroblast growth factor (bFGF) gene or bFGF antisense fene into human retinal pigment epithelial cells. Ogata, N., Nishizawa, M., Ando, A., Uyama, M. Graefes Arch. Clin. Exp. Ophthalmol. (1999) [Pubmed]
  34. Incidence of retinal disease following refractive surgery in 9,239 eyes. Ruiz-Moreno, J.M., Alió, J.L. Journal of refractive surgery (Thorofare, N.J. : 1995) (2003) [Pubmed]
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