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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Advances in immunotherapy of castration-resistant prostate cancer: bisphosphonates, phosphoantigens and more.

Medical progress has prolonged life expectancy in patients with castration-resistant prostate cancer; however, the lack of effective therapies has fuelled an intensive search for novel modalities, including immunotherapy. Human gammadelta T-cells can be activated by endogenous pyrophosphates (phosphoantigens), or by agents that provoke their accumulation. Among the latter, aminobisphosphonates are well-established in the clinic. In this review, the possibility that the intentional activation of gammadelta T-cells in vivo by phosphoantigens, or aminobisphosphonates and interleukin-2, may represent a promising target for the design of novel and highly innovative immunotherapy in patients with prostate cancer is discussed.[1]

References

  1. Advances in immunotherapy of castration-resistant prostate cancer: bisphosphonates, phosphoantigens and more. Dieli, F., Caccamo, N., Meraviglia, S. Curr. Opin. Investig. Drugs (2008) [Pubmed]
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