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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The role of hexamethylmelamine in the management of ovarian cancer.

Hexamethylmelamine has been recognized as having useful single-agent activity for the treatment of ovarian cancer for the past 25 years, with some patients surviving disease-free for periods in excess of 12 years. Data from recently analysed and mature trials demonstrate that the addition of hexamethylmelamine to first-line combination chemotherapy results in significant improvements in survival compared to what is achieved with regimens of cisplatin and cyclophosphamide with or without doxorubicin.[1]


  1. The role of hexamethylmelamine in the management of ovarian cancer. Schein, P.S., Scheffler, B., McCulloch, W. Cancer Treat. Rev. (1991) [Pubmed]
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