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Matsuda, Y. et al.

Yoshio Matsuda, Hidehito Kato, Erina Ono, Ken Kikuchi, Mitsue Muraoka, Koichiro Takagi, Ken'ichi Imanishi, Shun'ichi Itoh, Tatsuo Itoh, Tetsuya Ogawa, Kosaku Nitta, Sayaka Inokuchi, Toshifumi Hibi, Hiroaki Ohta, Takehiko Uchiyama,

Diagnosis of toxic shock syndrome by two different systems; clinical criteria and monitoring of TSST-1-reactive T cells.

Two methods of TSS diagnosis were evaluated: comparison of symptoms with clinical criteria and monitoring for evidence of selective activation of Vbeta2(+) T cells by the causative toxin, TSS toxin-1 (TSST-1). Ten patients with acute and systemic febrile infections caused by Staphylococcus aureus were monitored for increase in TSST-1-reactive Vbeta2(+) T cells during their clinical courses. Nine of the ten patients were diagnosed with TSS based on evidence of selective activation of Vbeta2(+) T cells by TSST-1; however, clinical symptoms met the clinical criteria for TSS in only six of these nine patients. In the remaining patient, clinical symptoms met the clinical criteria, but selective activation of Vbeta2(+) T cells was not observed. Time taken to reach the diagnosis of TSS could be significantly shortened by utilizing the findings from tracing Vbeta2(+) T cells. In vitro studies showed that TSST-1- reactive T cells from TSS patients were anergic in the early phase of their illness. Examining selective activation of Vbeta2(+) T cells could be a useful tool to supplement clinical criteria for early diagnosis of TSS.[1]

References

Diagnosis of toxic shock syndrome by two different systems; clinical criteria and monitoring of TSST-1-reactive T cells. Matsuda, Y., Kato, H., Ono, E., Kikuchi, K., Muraoka, M., Takagi, K., Imanishi, K., Itoh, S., Itoh, T., Ogawa, T., Nitta, K., Inokuchi, S., Hibi, T., Ohta, H., Uchiyama, T. Microbiol. Immunol. (2008) [Pubmed]

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