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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Early Diagnosis

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Disease relevance of Early Diagnosis

  • We conclude that the early diagnosis and treatment of suspected appendicitis in girls and women of reproductive age may reduce the incidence of tubal infertility resulting from the sequelae of a ruptured appendix [1].
  • An evaluation aimed at early diagnosis of the Zollinger-Ellison syndrome should be instituted in such patients and should begin with a determination of the fasting serum gastrin level [2].
  • METHODS: We developed a computer simulation model by use of information on population-based PSA testing patterns, cancer detection rates, average lead time (the time by which diagnosis is advanced by screening), and projected decreased risk of death associated with early diagnosis of prostate cancer through PSA testing [3].
  • INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance [4].
  • All acute-phase Lassa-fever sera contained either antigen or IgM antibody, and most contained both, thus allowing early diagnosis with single serum samples [5].

Psychiatry related information on Early Diagnosis


High impact information on Early Diagnosis


Chemical compound and disease context of Early Diagnosis


Biological context of Early Diagnosis


Anatomical context of Early Diagnosis


Associations of Early Diagnosis with chemical compounds


Gene context of Early Diagnosis


Analytical, diagnostic and therapeutic context of Early Diagnosis

  • Measurement of soluble IL2R may have a role in the early diagnosis of acute rejection and in identifying patients with chronic rejection in whom further immunosuppression will provide no benefit [41].
  • HLA typing provides some indication of the risk of I.H.C. in first-degree relatives, but the combination of serum-ferritin, serum-iron, and transferrin saturation remains the most reliable screening regimen for early diagnosis of I.H.C [42].
  • This molecular diagnostic technique has implications for prevention trials and for the early diagnosis of HCC [43].
  • These radiopeptides were composed of the first pan-bombesin radioligands, which show great promise for the early diagnosis of tumors bearing not only gastrin-releasing peptide-receptors but also the other two bombesin receptor subtypes and may be of use in targeted radiotherapy of these tumors [44].
  • Here we propose an early diagnosis method that utilises single photon emission computerized tomography (SPECT) coupled to the iodine-123-labelled selective dopamine transporter ligand N-(3-ioprop-2E-enyl)-2-beta-(4-methylphenyl)nortropane ((123)I-PE2I), applying Logan's graphical method for quantification [45].


  1. Appendectomy and the risk of tubal infertility. Mueller, B.A., Daling, J.R., Moore, D.E., Weiss, N.S., Spadoni, L.R., Stadel, B.V., Soules, M.R. N. Engl. J. Med. (1986) [Pubmed]
  2. Zollinger-Ellison syndrome. Current concepts in diagnosis and management. Wolfe, M.M., Jensen, R.T. N. Engl. J. Med. (1987) [Pubmed]
  3. Cancer surveillance series: interpreting trends in prostate cancer--part III: Quantifying the link between population prostate-specific antigen testing and recent declines in prostate cancer mortality. Etzioni, R., Legler, J.M., Feuer, E.J., Merrill, R.M., Cronin, K.A., Hankey, B.F. J. Natl. Cancer Inst. (1999) [Pubmed]
  4. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Nosten, F., van Vugt, M., Price, R., Luxemburger, C., Thway, K.L., Brockman, A., McGready, R., ter Kuile, F., Looareesuwan, S., White, N.J. Lancet (2000) [Pubmed]
  5. Early diagnosis of human Lassa fever by ELISA detection of antigen and antibody. Jahrling, P.B., Niklasson, B.S., McCormick, J.B. Lancet (1985) [Pubmed]
  6. Filamentous phage as vector-mediated antibody delivery to the brain. Frenkel, D., Solomon, B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. The incidence of Wernicke's encephalopathy in Australia--a neuropathological study of 131 cases. Harper, C. J. Neurol. Neurosurg. Psychiatr. (1983) [Pubmed]
  8. Comparison of somatosensory evoked potentials with striatal glucose consumption measured by positron emission tomography in the early diagnosis of Huntington's disease. Kuwert, T., Noth, J., Scholz, D., Schwarz, M., Lange, H.W., Töpper, R., Herzog, H., Aulich, A., Feinendegen, L.E. Mov. Disord. (1993) [Pubmed]
  9. Diagnosis of Angelman syndrome: clinical and EEG criteria. Buoni, S., Grosso, S., Pucci, L., Fois, A. Brain Dev. (1999) [Pubmed]
  10. General practitioners' views on the early diagnosis of dementia. Renshaw, J., Scurfield, P., Cloke, L., Orrell, M. The British journal of general practice : the journal of the Royal College of General Practitioners. (2001) [Pubmed]
  11. The cerebrohepatorenal (Zellweger) syndrome. Increased levels and impaired degradation of very-long-chain fatty acids and their use in prenatal diagnosis. Moser, A.E., Singh, I., Brown, F.R., Solish, G.I., Kelley, R.I., Benke, P.J., Moser, H.W. N. Engl. J. Med. (1984) [Pubmed]
  12. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Chandrasekharappa, S.C., Guru, S.C., Manickam, P., Olufemi, S.E., Collins, F.S., Emmert-Buck, M.R., Debelenko, L.V., Zhuang, Z., Lubensky, I.A., Liotta, L.A., Crabtree, J.S., Wang, Y., Roe, B.A., Weisemann, J., Boguski, M.S., Agarwal, S.K., Kester, M.B., Kim, Y.S., Heppner, C., Dong, Q., Spiegel, A.M., Burns, A.L., Marx, S.J. Science (1997) [Pubmed]
  13. Early diagnosis, genetic marker sought for tuberous sclerosis. Simmons, K. JAMA (1984) [Pubmed]
  14. Persistent nocardemia following renal transplantation. Association with pulmonary nocardiosis. Avram, M.M., Nair, S.R., Lipner, H.I., Cherubin, C.E. JAMA (1978) [Pubmed]
  15. Xenon ventilation-perfusion lung scans. The early diagnosis of inhalation injury. Schall, G.L., McDonald, H.D., Carr, L.B., Capozzi, A. JAMA (1978) [Pubmed]
  16. Incremental value of the leukocyte differential and the rapid creatine kinase-MB isoenzyme for the early diagnosis of myocardial infarction. Thomson, S.P., Gibbons, R.J., Smars, P.A., Suman, V.J., Pierre, R.V., Santrach, P.J., Jiang, N.S. Ann. Intern. Med. (1995) [Pubmed]
  17. Very early noninvasive detection of acute experimental nonreperfused myocardial infarction with 99mTc-labeled glucarate. Narula, J., Petrov, A., Pak, K.Y., Lister, B.C., Khaw, B.A. Circulation (1997) [Pubmed]
  18. Clinical images: Early diagnosis of Takayasu arteritis using gadolinium-enhanced magnetic resonance imaging. Iwamoto, M., Ogawa-Shirota, Y., Sato, H., Yoshio, T., Okazaki, H., Fujita, A., Sugimoto, H., Minota, S. Arthritis Rheum. (1999) [Pubmed]
  19. Invasive aspergillosis. Progress in early diagnosis and treatment. Fisher, B.D., Armstrong, D., Yu, B., Gold, J.W. Am. J. Med. (1981) [Pubmed]
  20. Prospective study of lower respiratory tract infections in an extended-care nursing home program: potential role of oral ciprofloxacin. Peterson, P.K., Stein, D., Guay, D.R., Logan, G., Obaid, S., Gruninger, R., Davies, S., Breitenbucher, R. Am. J. Med. (1988) [Pubmed]
  21. Toward earlier diagnosis of amyotrophic lateral sclerosis: revised criteria. rhCNTF ALS Study Group. Ross, M.A., Miller, R.G., Berchert, L., Parry, G., Barohn, R.J., Armon, C., Bryan, W.W., Petajan, J., Stromatt, S., Goodpasture, J., McGuire, D. Neurology (1998) [Pubmed]
  22. Four common mutations of the cystathionine beta-synthase gene detected by multiplex PCR and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Harksen, A., Ueland, P.M., Refsum, H., Meyer, K. Clin. Chem. (1999) [Pubmed]
  23. Liver transplantation in patients with severe portopulmonary hypertension treated with preoperative chronic intravenous epoprostenol. Tan, H.P., Markowitz, J.S., Montgomery, R.A., Merritt, W.T., Klein, A.S., Thuluvath, P.J., Poordad, F.F., Maley, W.R., Winters, B., Akinci, S.B., Gaine, S.P. Liver Transpl. (2001) [Pubmed]
  24. Herpes simplex encephalitis after brain surgery: case report and review of the literature. Spuler, A., Blaszyk, H., Parisi, J.E., Davis, D.H. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  25. Sodium-hydrogen antiporter: its possible role in the genesis of diabetic nephropathy. Trevisan, R., Viberti, G. Nephrol. Dial. Transplant. (1997) [Pubmed]
  26. Morphology of rapidly adhering amniotic-fluid cells as an aid to the diagnosis of neural-tube defects. Gosden, C.M., Brock, D.J. Lancet (1977) [Pubmed]
  27. Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer. Berthélemy, P., Bouisson, M., Escourrou, J., Vaysse, N., Rumeau, J.L., Pradayrol, L. Ann. Intern. Med. (1995) [Pubmed]
  28. A disorder of biogenic amines in dihydropteridine reductase deficiency. Butler, I.J., Koslow, S.H., Krumholz, A., Holtzman, N.A., Kaufman, S. Ann. Neurol. (1978) [Pubmed]
  29. Expression of the PDGF alpha-receptor 1.5 kb transcript, OCT-4, and c-KIT in human normal and malignant tissues. Implications for the early diagnosis of testicular germ cell tumours and for our understanding of regulatory mechanisms. Palumbo, C., van Roozendaal, K., Gillis, A.J., van Gurp, R.H., de Munnik, H., Oosterhuis, J.W., van Zoelen, E.J., Looijenga, L.H. J. Pathol. (2002) [Pubmed]
  30. Determination of lactate concentrations in cerebrospinal fluid for rapid diagnosis early in bacterial meningitis. Donald, P.R., Malan, C., Dykman, J.H. J. Infect. Dis. (1982) [Pubmed]
  31. Qualitative and quantitative changes in sialomucins during 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat. McGarrity, T.J., Via, E.A., Colony, P.C. J. Natl. Cancer Inst. (1987) [Pubmed]
  32. Diabetic neuropathy. Greene, D.A., Sima, A.F., Pfeifer, M.A., Albers, J.W. Annu. Rev. Med. (1990) [Pubmed]
  33. Azathioprine hepatotoxicity after liver transplantation. Sterneck, M., Wiesner, R., Ascher, N., Roberts, J., Ferrell, L., Ludwig, J., Lake, J. Hepatology (1991) [Pubmed]
  34. Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease. O'Rourke, T., George, C.B., Redmond, J., Davidson, H., Cornett, P., Fill, W.L., Spring, D.B., Sobel, D., Dabe, I.B., Karl, R.D. J. Clin. Oncol. (1986) [Pubmed]
  35. Magnetic resonance imaging and spectroscopic changes in brains of patients with cerebrotendinous xanthomatosis. De Stefano, N., Dotti, M.T., Mortilla, M., Federico, A. Brain (2001) [Pubmed]
  36. Population screening for hemochromatosis: a comparison of unbound iron-binding capacity, transferrin saturation, and C282Y genotyping in 5,211 voluntary blood donors. Adams, P.C., Kertesz, A.E., McLaren, C.E., Barr, R., Bamford, A., Chakrabarti, S. Hepatology (2000) [Pubmed]
  37. Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death: early diagnosis of asymptomatic carriers. Bauce, B., Rampazzo, A., Basso, C., Bagattin, A., Daliento, L., Tiso, N., Turrini, P., Thiene, G., Danieli, G.A., Nava, A. J. Am. Coll. Cardiol. (2002) [Pubmed]
  38. Expression of prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) in ileum and other extraprostatic tissues. Olsson, A.Y., Bjartell, A., Lilja, H., Lundwall, A. Int. J. Cancer (2005) [Pubmed]
  39. Genetic testing for Alzheimer disease. Practical and ethical issues. Roses, A.D. Arch. Neurol. (1997) [Pubmed]
  40. Early diagnosis and treatment of rheumatoid arthritis for improved outcomes: focus on etanercept, a new biologic response modifier. Fleischmann, R.M. Clinical therapeutics. (1999) [Pubmed]
  41. Soluble interleukin-2 receptors in serum and bile of liver transplant recipients. Adams, D.H., Wang, L., Hubscher, S.G., Elias, E., Neuberger, J.M. Lancet (1989) [Pubmed]
  42. Early detection of idiopathic haemochromatosis: relative value of serum-ferritin and HLA typing. Bassett, M.L., Halliday, J.W., Powell, L.W., Doran, T., Bashir, H. Lancet (1979) [Pubmed]
  43. Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry. Jackson, P.E., Qian, G.S., Friesen, M.D., Zhu, Y.R., Lu, P., Wang, J.B., Wu, Y., Kensler, T.W., Vogelstein, B., Groopman, J.D. Cancer Res. (2001) [Pubmed]
  44. Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors. Zhang, H., Chen, J., Waldherr, C., Hinni, K., Waser, B., Reubi, J.C., Maecke, H.R. Cancer Res. (2004) [Pubmed]
  45. Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT. Prunier, C., Bézard, E., Montharu, J., Mantzarides, M., Besnard, J.C., Baulieu, J.L., Gross, C., Guilloteau, D., Chalon, S. Neuroimage (2003) [Pubmed]
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