Disease relevance of Early Diagnosis

• We conclude that the early diagnosis and treatment of suspected appendicitis in girls and women of reproductive age may reduce the incidence of tubal infertility resulting from the sequelae of a ruptured appendix [1].
• An evaluation aimed at early diagnosis of the Zollinger-Ellison syndrome should be instituted in such patients and should begin with a determination of the fasting serum gastrin level [2].
• METHODS: We developed a computer simulation model by use of information on population-based PSA testing patterns, cancer detection rates, average lead time (the time by which diagnosis is advanced by screening), and projected decreased risk of death associated with early diagnosis of prostate cancer through PSA testing [3].
• INTERPRETATION: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance [4].
• All acute-phase Lassa-fever sera contained either antigen or IgM antibody, and most contained both, thus allowing early diagnosis with single serum samples [5].

Psychiatry related information on Early Diagnosis

• The ability to image A beta deposits in vivo would arguably provide the most useful diagnostic and monitoring test for early diagnosis of Alzheimer's disease [6].
• Thus, Wernicke's encephalopathy could be considered a "progressive" disorder and as patients respond well to thiamine replacement therapy, early diagnosis is important [7].
• Comparison of somatosensory evoked potentials with striatal glucose consumption measured by positron emission tomography in the early diagnosis of Huntington's disease [8].
• In order to evaluate which diagnostic criteria can be indicative for an early diagnosis of Angelman syndrome (AS), 144 children with severe epilepsy and mental retardation were evaluated [9].
• This study investigated the views on the early diagnosis of dementia from over 1000 general practitioners (GPs) from 12 Health Authority areas in England and Wales. Almost half of the GPs did not believe it was beneficial to make an early diagnosis, yet most admitted they needed more training in the area [10].

High impact information on Early Diagnosis

• The study of very-long-chain fatty acids provides a convenient method for the early diagnosis and prenatal detection of the Zellweger syndrome [11].
• The identification of MEN1 will enable improved understanding of the mechanism of endocrine tumorigenesis and should facilitate early diagnosis [12].
• Early diagnosis, genetic marker sought for tuberous sclerosis [13].
• The remaining kidney function was preserved, and the patient had a very favorable outcome because of early diagnosis and prompt treatment with sulfisoxazole [14].
• The use of xenon Xe 133 ventilation-perfusion lung scans for the early diagnosis of inhalation injury was evaluated in 67 patients with acute thermal burns [15].

Chemical compound and disease context of Early Diagnosis

• Incremental value of the leukocyte differential and the rapid creatine kinase-MB isoenzyme for the early diagnosis of myocardial infarction [16].
• The feasibility of imaging with 99mTc glucarate was evaluated for the early diagnosis of nonreperfused and reperfused myocardial infarction and compared with localization of simultaneously administered 111In anti-myosin [17].
• Clinical images: Early diagnosis of Takayasu arteritis using gadolinium-enhanced magnetic resonance imaging [18].
• Invasive aspergillosis. Progress in early diagnosis and treatment [19].
• Following the establishment of a teaching Extended-Care Nursing Home Program, which facilitated the early diagnosis and therapy of bronchopulmonary infections, a comparative trial of oral ciprofloxacin and intramuscular cefamandole was initiated in elderly patients with lower respiratory tract infections [20].

Biological context of Early Diagnosis

• We modified the World Federation of Neurology (WFN) diagnostic criteria for ALS to facilitate early diagnosis and used these criteria for enrollment of ALS patients in a clinical trial [21].
• The effect of therapy is related to the underlying CBS genotype, which makes early diagnosis of this genetic defect important [22].
• The pre-OLT management of patients with PPHTN requires early diagnosis and chronic therapy with intravenous epoprostenol to decrease pulmonary vascular resistance (PVR) [23].
• Recent diagnostic tools, including detection of herpes viral DNA sequences by polymerase chain reaction, complement clinical suspicion and facilitate mandatory early diagnosis, because herpes encephalitis, without rapid initiation of treatment, may lead to severe disability or death [24].
• Such intermediate phenotypes can be useful for early diagnosis and would help clarify the molecular mechanisms leading to diabetic nephropathy [25].

Anatomical context of Early Diagnosis

• It is suggested that the techniques described here will be useful adjuncts to amniotic-fluid alpha-fetoprotein determination in the early diagnosis of fetal abnormality, particularly in blood-stained samples [26].
• Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer [27].
• DHPR activity in cultured skin fibroblasts of children with persistent hyperphenylalaninemia should permit early diagnosis and early treatment of this disorder [28].
• Expression of the PDGF alpha-receptor 1.5 kb transcript, OCT-4, and c-KIT in human normal and malignant tissues. Implications for the early diagnosis of testicular germ cell tumours and for our understanding of regulatory mechanisms [29].
• Determination of lactate concentrations in cerebrospinal fluid for rapid diagnosis early in bacterial meningitis [30].

Associations of Early Diagnosis with chemical compounds

• These studies indicated that tissue sialic acid levels may provide a simple and reliable screening technique in the early diagnosis of premalignant change in all regions of the colon [31].
• Therapy is directed at early diagnosis, exclusion of other neuropathic disorders, prudent glucose control, and avoidance of secondary complications of neuropathy such as foot ulceration by aggressive foot care, hygiene, and patient education [32].
• Thus early diagnosis of azathioprine hepatotoxicity is of great importance [33].
• Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease [34].
• Early diagnosis of the disease is particularly important as patients benefit from therapy with chenodeoxycholic acid [35].

Gene context of Early Diagnosis

• Early diagnosis and treatment of hemochromatosis is essential to prevent organ damage [36].
• CONCLUSIONS: The absence of symptoms and PVA on the stress test in more than one-third of carriers of RyR2 mutations, as well as the lack of PVA inducibility by the EP study, underlies the importance of genetic screening for the early diagnosis of asymptomatic carriers and prevention of sudden death [37].
• In the literature, there are reports of nonprostatic expression of PSA that potentially can affect early diagnosis [38].
• Recent large, collaborative studies have found that when ApoE genotyping is used sequentially in diagnosis following criteria-based evaluations, the specificity of early diagnosis is significantly increased [39].
• Early diagnosis and treatment of rheumatoid arthritis for improved outcomes: focus on etanercept, a new biologic response modifier [40].

Analytical, diagnostic and therapeutic context of Early Diagnosis

• Measurement of soluble IL2R may have a role in the early diagnosis of acute rejection and in identifying patients with chronic rejection in whom further immunosuppression will provide no benefit [41].
• HLA typing provides some indication of the risk of I.H.C. in first-degree relatives, but the combination of serum-ferritin, serum-iron, and transferrin saturation remains the most reliable screening regimen for early diagnosis of I.H.C [42].
• This molecular diagnostic technique has implications for prevention trials and for the early diagnosis of HCC [43].
• These radiopeptides were composed of the first pan-bombesin radioligands, which show great promise for the early diagnosis of tumors bearing not only gastrin-releasing peptide-receptors but also the other two bombesin receptor subtypes and may be of use in targeted radiotherapy of these tumors [44].
• Here we propose an early diagnosis method that utilises single photon emission computerized tomography (SPECT) coupled to the iodine-123-labelled selective dopamine transporter ligand N-(3-ioprop-2E-enyl)-2-beta-(4-methylphenyl)nortropane ((123)I-PE2I), applying Logan's graphical method for quantification [45].

References