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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Accelerated metabolism of voriconazole and its partial reversal by cimetidine.

We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme inhibitor.[1]

References

  1. Accelerated metabolism of voriconazole and its partial reversal by cimetidine. Moriyama, B., Elinoff, J., Danner, R.L., Gea-Banacloche, J., Pennick, G., Rinaldi, M.G., Walsh, T.J. Antimicrob. Agents Chemother. (2009) [Pubmed]
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