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Tanabe, M. et al.

Mitsuo Tanabe, Koto Ono, Motoko Honda, Hideki Ono,

Gabapentin and pregabalin ameliorate mechanical hypersensitivity after spinal cord injury in mice.

The antiepileptic drugs gabapentin and pregabalin exhibit well-established analgesic effects in patients with several neuropathic conditions. In the present study, we examined their effects on mechanical hypersensitivity in mice subjected to weight-drop spinal cord injury. Hindlimb motor function and mechanical hypersensitivity were evaluated using the Basso-Beattie-Bresnahan (BBB) locomotor rating scale and the von Frey test, respectively, for 4 weeks after spinal cord injury. Despite gradual recovery of hindlimb motor function after spinal cord injury, mice exhibited continuous development of mechanical hypersensitivity. Gabapentin (30 and 100 mg/kg) and pregabalin (10 and 30 mg/kg), administered intraperitoneally on the 28th day after spinal cord injury, reduced mechanical hypersensitivity in a dose-dependent manner. These results suggest that gabapentin and pregabalin could be useful therapeutic tools for patients with neuropathic pain after spinal cord injury.[1]

References

Gabapentin and pregabalin ameliorate mechanical hypersensitivity after spinal cord injury in mice. Tanabe, M., Ono, K., Honda, M., Ono, H. Eur. J. Pharmacol. (2009) [Pubmed]

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