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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Hypersensitivity

 
 
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Disease relevance of Hypersensitivity

 

Psychiatry related information on Hypersensitivity

 

High impact information on Hypersensitivity

  • Biallelic disruption of FANCD2 results in both MMC and IR hypersensitivity [11].
  • We propose that synergy of D2 and A2 confers ethanol hypersensitivity and that betagamma dimers are required for voluntary drinking [12].
  • Although in all three cases the predicted proteins were different from wild type, their cDNAs complemented the characteristic hypersensitivity of FA cells to crosslinking agents, thus establishing a functional correction to wild type [13].
  • These data define a specific role for neurofibromin in negatively regulating GM-CSF signaling through Ras in haematopoietic cells and they suggest that hypersensitivity to GM-CSF may be a primary event in the development of JCML [14].
  • Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia [15].
 

Chemical compound and disease context of Hypersensitivity

 

Biological context of Hypersensitivity

 

Anatomical context of Hypersensitivity

 

Gene context of Hypersensitivity

  • Disruption of the CBF1 gene caused a decrease in the growth rate, an increase in the rate of chromosome loss/nondisjunction, and hypersensitivity to the antimitotic drug thiabendazole [31].
  • An SSL2 allele made to resemble the defective ERCC-3 gene confers UV light hypersensitivity to yeast cells [32].
  • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [33].
  • SOCS-3 transgenic mice showed increased T(H)2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system [34].
  • Moreover, although somatic apoptosis is unaffected, cep-1 mutants show hypersensitivity to hypoxia-induced lethality and decreased longevity in response to starvation-induced stress [35].
  • Our data show that HSP70 gene variants are associated with serious CBZ hypersensitivity reactions, but whether this is causal or reflects LD with another gene within the MHC requires further study [36].
  • The behavioral hypersensitivity was partially dependent on both TRPV1 and ASIC3 because deletions of either of these genes blunted zymosan's effect, suggesting that these proteins may be important peripheral mediators for development of functional (ie, noninflammatory) visceral hypersensitivity [37].
 

Analytical, diagnostic and therapeutic context of Hypersensitivity

References

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