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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hypersensitivity


Psychiatry related information on Hypersensitivity


High impact information on Hypersensitivity

  • Biallelic disruption of FANCD2 results in both MMC and IR hypersensitivity [11].
  • We propose that synergy of D2 and A2 confers ethanol hypersensitivity and that betagamma dimers are required for voluntary drinking [12].
  • Although in all three cases the predicted proteins were different from wild type, their cDNAs complemented the characteristic hypersensitivity of FA cells to crosslinking agents, thus establishing a functional correction to wild type [13].
  • These data define a specific role for neurofibromin in negatively regulating GM-CSF signaling through Ras in haematopoietic cells and they suggest that hypersensitivity to GM-CSF may be a primary event in the development of JCML [14].
  • Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia [15].

Chemical compound and disease context of Hypersensitivity


Biological context of Hypersensitivity


Anatomical context of Hypersensitivity


Gene context of Hypersensitivity

  • Disruption of the CBF1 gene caused a decrease in the growth rate, an increase in the rate of chromosome loss/nondisjunction, and hypersensitivity to the antimitotic drug thiabendazole [31].
  • An SSL2 allele made to resemble the defective ERCC-3 gene confers UV light hypersensitivity to yeast cells [32].
  • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [33].
  • SOCS-3 transgenic mice showed increased T(H)2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system [34].
  • Moreover, although somatic apoptosis is unaffected, cep-1 mutants show hypersensitivity to hypoxia-induced lethality and decreased longevity in response to starvation-induced stress [35].
  • Our data show that HSP70 gene variants are associated with serious CBZ hypersensitivity reactions, but whether this is causal or reflects LD with another gene within the MHC requires further study [36].
  • The behavioral hypersensitivity was partially dependent on both TRPV1 and ASIC3 because deletions of either of these genes blunted zymosan's effect, suggesting that these proteins may be important peripheral mediators for development of functional (ie, noninflammatory) visceral hypersensitivity [37].

Analytical, diagnostic and therapeutic context of Hypersensitivity


  1. Increased plasma histamine concentrations after food challenges in children with atopic dermatitis. Sampson, H.A., Jolie, P.L. N. Engl. J. Med. (1984) [Pubmed]
  2. The diagnosis and treatment of baroreflex failure. Robertson, D., Hollister, A.S., Biaggioni, I., Netterville, J.L., Mosqueda-Garcia, R., Robertson, R.M. N. Engl. J. Med. (1993) [Pubmed]
  3. Essential role for Gab2 in the allergic response. Gu, H., Saito, K., Klaman, L.D., Shen, J., Fleming, T., Wang, Y., Pratt, J.C., Lin, G., Lim, B., Kinet, J.P., Neel, B.G. Nature (2001) [Pubmed]
  4. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Demetriou, M., Granovsky, M., Quaggin, S., Dennis, J.W. Nature (2001) [Pubmed]
  5. FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Ioan-Facsinay, A., de Kimpe, S.J., Hellwig, S.M., van Lent, P.L., Hofhuis, F.M., van Ojik, H.H., Sedlik, C., da Silveira, S.A., Gerber, J., de Jong, Y.F., Roozendaal, R., Aarden, L.A., van den Berg, W.B., Saito, T., Mosser, D., Amigorena, S., Izui, S., van Ommen, G.J., van Vugt, M., van de Winkel, J.G., Verbeek, J.S. Immunity (2002) [Pubmed]
  6. Adaptations of alpha2- and beta-cells of rat and mouse pancreatic islets to starvation, to refeeding after starvation, and to obesity. Matschinsky, F.M., Rujanavech, C., Pagliara, A., Norfleet, W.T. J. Clin. Invest. (1980) [Pubmed]
  7. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Willert, R.P., Woolf, C.J., Hobson, A.R., Delaney, C., Thompson, D.G., Aziz, Q. Gastroenterology (2004) [Pubmed]
  8. Differential carbon dioxide sensitivity in childhood anxiety disorders and nonill comparison group. Pine, D.S., Klein, R.G., Coplan, J.D., Papp, L.A., Hoven, C.W., Martinez, J., Kovalenko, P., Mandell, D.J., Moreau, D., Klein, D.F., Gorman, J.M. Arch. Gen. Psychiatry (2000) [Pubmed]
  9. Gilles de la Tourette syndrome after long-term chlorpromazine therapy. Klawans, H.L., Falk, D.K., Nausieda, P.A., Weiner, W.J. Neurology (1978) [Pubmed]
  10. The safety profile of paroxetine. Boyer, W.F., Blumhardt, C.L. The Journal of clinical psychiatry. (1992) [Pubmed]
  11. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Taniguchi, T., Garcia-Higuera, I., Xu, B., Andreassen, P.R., Gregory, R.C., Kim, S.T., Lane, W.S., Kastan, M.B., D'Andrea, A.D. Cell (2002) [Pubmed]
  12. betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Yao, L., Arolfo, M.P., Dohrman, D.P., Jiang, Z., Fan, P., Fuchs, S., Janak, P.H., Gordon, A.S., Diamond, I. Cell (2002) [Pubmed]
  13. Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism. Waisfisz, Q., Morgan, N.V., Savino, M., de Winter, J.P., van Berkel, C.G., Hoatlin, M.E., Ianzano, L., Gibson, R.A., Arwert, F., Savoia, A., Mathew, C.G., Pronk, J.C., Joenje, H. Nat. Genet. (1999) [Pubmed]
  14. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Bollag, G., Clapp, D.W., Shih, S., Adler, F., Zhang, Y.Y., Thompson, P., Lange, B.J., Freedman, M.H., McCormick, F., Jacks, T., Shannon, K. Nat. Genet. (1996) [Pubmed]
  15. Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Largaespada, D.A., Brannan, C.I., Jenkins, N.A., Copeland, N.G. Nat. Genet. (1996) [Pubmed]
  16. Inhibition of mediator release in allergic rhinitis by pretreatment with topical glucocorticosteroids. Pipkorn, U., Proud, D., Lichtenstein, L.M., Kagey-Sobotka, A., Norman, P.S., Naclerio, R.M. N. Engl. J. Med. (1987) [Pubmed]
  17. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. Mattson, R.H., Cramer, J.A., Collins, J.F., Smith, D.B., Delgado-Escueta, A.V., Browne, T.R., Williamson, P.D., Treiman, D.M., McNamara, J.O., McCutchen, C.B. N. Engl. J. Med. (1985) [Pubmed]
  18. Hypersensitivity to cimetidine. Delaunois, L. N. Engl. J. Med. (1979) [Pubmed]
  19. Immunologic components of hypersensitivity reactions to cromolyn sodium. Sheffer, A.L., Rocklin, R.E., Goetzl, E.J. N. Engl. J. Med. (1975) [Pubmed]
  20. Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial. Ellis, C.N., Fradin, M.S., Messana, J.M., Brown, M.D., Siegel, M.T., Hartley, A.H., Rocher, L.L., Wheeler, S., Hamilton, T.A., Parish, T.G. N. Engl. J. Med. (1991) [Pubmed]
  21. Localisation of the Fanconi anaemia complementation group A gene to chromosome 16q24.3. Pronk, J.C., Gibson, R.A., Savoia, A., Wijker, M., Morgan, N.V., Melchionda, S., Ford, D., Temtamy, S., Ortega, J.J., Jansen, S. Nat. Genet. (1995) [Pubmed]
  22. Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain. Emerson, B.M., Lewis, C.D., Felsenfeld, G. Cell (1985) [Pubmed]
  23. Alloantigen-specific suppressor t cells can also suppress the in vivo immune response to unrelated alloantigens. Bianchi, A.T., Bril, H., Benner, R. Nature (1983) [Pubmed]
  24. ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Tsukiyama, T., Becker, P.B., Wu, C. Nature (1994) [Pubmed]
  25. 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway. Yamashita, Y.M., Nakaseko, Y., Samejima, I., Kumada, K., Yamada, H., Michaelson, D., Yanagida, M. Nature (1996) [Pubmed]
  26. A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia. Castleberry, R.P., Emanuel, P.D., Zuckerman, K.S., Cohn, S., Strauss, L., Byrd, R.L., Homans, A., Chaffee, S., Nitschke, R., Gualtieri, R.J. N. Engl. J. Med. (1994) [Pubmed]
  27. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Sallusto, F., Mackay, C.R., Lanzavecchia, A. Science (1997) [Pubmed]
  28. Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene. Aronow, B., Lattier, D., Silbiger, R., Dusing, M., Hutton, J., Jones, G., Stock, J., McNeish, J., Potter, S., Witte, D. Genes Dev. (1989) [Pubmed]
  29. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. McGargill, M.A., Wen, B.G., Walsh, C.M., Hedrick, S.M. Immunity (2004) [Pubmed]
  30. Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Takaki, S., Sauer, K., Iritani, B.M., Chien, S., Ebihara, Y., Tsuji, K., Takatsu, K., Perlmutter, R.M. Immunity (2000) [Pubmed]
  31. Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy. Cai, M., Davis, R.W. Cell (1990) [Pubmed]
  32. SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3. Gulyas, K.D., Donahue, T.F. Cell (1992) [Pubmed]
  33. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D.S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P., Bradley, A. Nature (1997) [Pubmed]
  34. SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Seki, Y., Inoue, H., Nagata, N., Hayashi, K., Fukuyama, S., Matsumoto, K., Komine, O., Hamano, S., Himeno, K., Inagaki-Ohara, K., Cacalano, N., O'Garra, A., Oshida, T., Saito, H., Johnston, J.A., Yoshimura, A., Kubo, M. Nat. Med. (2003) [Pubmed]
  35. Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Derry, W.B., Putzke, A.P., Rothman, J.H. Science (2001) [Pubmed]
  36. Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., Smith, J.C., March, R.E., Barratt, B.J., Chadwick, D.W., Kevin Park, B., Pirmohamed, M. Pharmacogenet. Genomics (2006) [Pubmed]
  37. Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse. Jones, R.C., Otsuka, E., Wagstrom, E., Jensen, C.S., Price, M.P., Gebhart, G.F. Gastroenterology (2007) [Pubmed]
  38. Antilymphoblast globulin in renal transplant patients. No allergic reactions. Martin, W.J., Blumenthal, M., Roitman, B., Condie, R., Simmons, R., Najarian, J. JAMA (1976) [Pubmed]
  39. Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. Vogt, A., Chuang, P.T., Hebert, J., Hwang, J., Lu, Y., Kopelovich, L., Athar, M., Bickers, D.R., Epstein, E.H. J. Exp. Med. (2004) [Pubmed]
  40. Antigen- and receptor-driven regulatory mechanisms. III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies. Sy, M.S., Brown, A.R., Benacerraf, B., Greene, M.I. J. Exp. Med. (1980) [Pubmed]
  41. Hypersensitivity reactions to chemotherapy agents in patients receiving chemoimmunotherapy with high-dose interleukin 2. Heywood, G.R., Rosenberg, S.A., Weber, J.S. J. Natl. Cancer Inst. (1995) [Pubmed]
  42. Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. Pipkorn, U., Proud, D., Lichtenstein, L.M., Schleimer, R.P., Peters, S.P., Adkinson, N.F., Kagey-Sobotka, A., Norman, P.S., Naclerio, R.M. J. Clin. Invest. (1987) [Pubmed]
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