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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Guazzarotti, L. et al.

Laura Guazzarotti, Daria Trabattoni, Eleonora Castelletti, Benedetta Boldrighini, Luca Piacentini, Piergiorgio Duca, Silvia Beretta, Michela Pacei, Cristiana Caprio, Alessandra Vigan Ago, Berardo di Natale, Gian Vincenzo Zuccotti, Mario Clerici,

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome).

Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.[1]

References

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome). Guazzarotti, L., Trabattoni, D., Castelletti, E., Boldrighini, B., Piacentini, L., Duca, P., Beretta, S., Pacei, M., Caprio, C., Vigan Ago, A., di Natale, B., Zuccotti, G.V., Clerici, M. Am. J. Intellect. Dev. Disabil (2009) [Pubmed]

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