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Robertson, J.F. et al.

J. F. R. Robertson, G.G. Steger, P. Neven, S. Barni, F. Gieseking, F. Nolè, K.I. Pritchard, F.P. O'Malley, S.D. Simon, B. Kaufman, L. Petruzelka,

Activity of fulvestrant in HER2-overexpressing advanced breast cancer.

BACKGROUND: Human epidermal growth factor receptor 2 (HER2) overexpression increases the aggressiveness of breast cancer cells resulting in poorer prognosis. Patients with HER2-positive disease are less responsive to endocrine therapies. Trastuzumab monotherapy results in objective responses in only approximately 15% of patients. Fulvestrant retains activity in cells overexpressing HER2 that are resistant to other endocrine treatments. This retrospective study evaluated response to fulvestrant treatment among HER2-positive patients with advanced breast cancer (ABC). PATIENTS AND METHODS: Clinical experience data from 10 treatment centres were pooled. Postmenopausal patients with predominantly hormone receptor-positive and HER2-positive disease were included. Clinical benefit (CB) was defined as the proportion of patients achieving a response to treatment (partial or complete) or stable disease lasting >/=6 months. RESULTS: Data for 102 patients were analysed. Fulvestrant resulted in an overall CB rate of 42% (43/101) in HER2-positive patients and 40% (25/63) in patients with visceral disease. Median duration of treatment was 14.5 months (range 6-44 months). Fulvestrant showed activity up to the fourth line of endocrine therapy and up to the seventh line of overall therapy. CONCLUSIONS: Results indicate that fulvestrant may be a suitable treatment option in extensively pre-treated patients with HER2-positive, hormone receptor-positive ABC. Further exploration of its use in this patient population is warranted.[1]

References

Activity of fulvestrant in HER2-overexpressing advanced breast cancer. Robertson, J.F., Steger, G.G., Neven, P., Barni, S., Gieseking, F., Nolè, F., Pritchard, K.I., O'Malley, F.P., Simon, S.D., Kaufman, B., Petruzelka, L. Ann. Oncol. (2010) [Pubmed]

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