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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genotoxicity of the fungicide dichlofluanid in seven assays.

Seven different endpoints for detection of genotoxicity have been used to demonstrate the DNA-altering properties of Dichlofluanid, a fungicide commonly used in viticulture pest control. Each endpoint (DNA synthesis inhibition test, alkaline viscosimetry, umu-test, alkaline filter elution, FADU-test, 32P-postlabeling, and electron microscopy) shows clear evidence of genotoxicity. These data indicate that application of the fungicide dichlofluanid may be mutagenic and/or carcinogenic for exposed humans.[1]


  1. Genotoxicity of the fungicide dichlofluanid in seven assays. Heil, J., Reifferscheid, G., Hellmich, D., Hergenröder, M., Zahn, R.K. Environ. Mol. Mutagen. (1991) [Pubmed]
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