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Godfrey, D.I. et al.

Dale I. Godfrey, Daniel G. Pellicci, Onisha Patel, Lars Kjer-Nielsen, James McCluskey, Jamie Rossjohn,

Antigen recognition by CD1d-restricted NKT T cell receptors.

alphabeta T cell receptors (TCRs) have traditionally been viewed as receptors for peptide antigens presented by either Major Histocompatibility Complex (MHC) class I (for CD8 T cells) or MHC class II (for CD4 T cells) antigen-presenting molecules. However, it is now clear that some T cell lineages express TCRs that are specialized for recognition of lipid-based antigens presented by the MHC class I-like CD1 family. Recently, the molecular basis for the TCR recognition of glycolipid antigens presented by CD1d has revealed an evolutionarily conserved-docking mode that is distinct from that of peptide-based recognition. T cells carrying these receptors follow a unique developmental pathway that results not only in unconventional antigen specificity, but also seemingly exaggerated functional capabilities, which makes these cells and their antigens highly attractive targets for immunotherapeutic manipulation.[1]

References

Antigen recognition by CD1d-restricted NKT T cell receptors. Godfrey, D.I., Pellicci, D.G., Patel, O., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. Semin. Immunol. (2010) [Pubmed]

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