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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The molecular basis of the host response to lipopolysaccharide.

Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate pro-inflammatory signalling pathways. The TLR4-MD2 receptor complex is crucial for the host recognition of Gram-negative bacterial infection, and pathogens have devised many strategies to evade or manipulate TLR4-MD2 activity. The TLR4-MD2 signalling pathway is therefore potentially an important therapeutic target. This Progress article focuses on recent exciting data that have revealed the structural basis of TLR4-MD2 recognition of LPS.[1]

References

  1. The molecular basis of the host response to lipopolysaccharide. Bryant, C.E., Spring, D.R., Gangloff, M., Gay, N.J. Nat. Rev. Microbiol. (2010) [Pubmed]
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