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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.

CENP-A, a centromere-specific 17-kDa protein, has histone-like properties. However, in contrast to the common somatic histones, CENP-A is quantitatively retained in bull spermatozoa, and we have exploited this fact to purify CENP-A to apparent homogeneity. Partial sequence analysis of the purified protein indicates that CENP-A is a distinctive gene product. Some CENP-A sequences are highly similar to regions of histone H3. Other segments of CENP-A are not related to H3 or any other histone. These unrelated segments are presumably involved in localizing CENP-A to centromeric DNA or in centromere-specific functions of CENP-A.[1]

References

  1. Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. Palmer, D.K., O'Day, K., Trong, H.L., Charbonneau, H., Margolis, R.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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