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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Rosenheck, R. et al.

Robert Rosenheck, Marvin Swartz, Joseph McEvoy, T. Scott Stroup, Sonia Davis, Richard Se Keefe, John Hsiao, Jeffrey Lieberman,

Second-generation antipsychotics: reviewing the cost-effectiveness component of the CATIE trial.

The cost-effectiveness component of the 18-month CATIE trial of schizophrenia pharmacotherapy (n = 1460) showed that the first-generation antipsychotic perphenazine was US$300-600 per month less expensive than each of four second-generation antipsychotics, and no less effective across multiple measures. We consider whether or not each of eight potential methodological limitations could weaken this conclusion: follow-up rates, study duration, sample characteristics, the choice of outcome measures, exclusion of patients with tardive dyskinesia from assignment to perphenazine, choice of study drugs and doses, reliance on intention-to-treat analysis, and differences in prestudy treatment. We conclude that results of CATIE are robust to these limitations. Perphenazine seems to have been a more representative choice for first-generation antipsychotic comparison treatment than haloperidol.[1]

References

Second-generation antipsychotics: reviewing the cost-effectiveness component of the CATIE trial. Rosenheck, R., Swartz, M., McEvoy, J., Stroup, T.S., Davis, S., Keefe, R.S., Hsiao, J., Lieberman, J. Expert. Rev. Pharmacoecon. Outcomes. Res (2007) [Pubmed]

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