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Pharmacokinetics of eltoprazine in healthy subjects.

The pharmacokinetics of eltoprazine in healthy male subjects was investigated after intravenous and oral dosing in one study, and after oral dosing of 14C-eltoprazine in a second study. It was shown that the absorption of eltoprazine from the gastro-intestinal tract was complete, and that absolute bioavailability was 100%. The mean elimination half-life of eltoprazine in plasma was about 8 hours. Approximately 40% of the dose was excreted unchanged in urine.[1]

References

  1. Pharmacokinetics of eltoprazine in healthy subjects. van Harten, J., Mathlener, I.S., Raghoebar, M. Drug metabolism and drug interactions. (1990) [Pubmed]
 
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