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Gambichler, T. et al.

T. Gambichler, S. Kobus, A. Kobus, C. Tigges, N. Scola, P. Altmeyer, A. Kreuter, F.G. Bechara, M. Skrygan,

Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients.

Recent papers highlight the role of dysregulated expression of antimicrobial peptides and proteins (AMPs) in the pathogenesis of psoriasis. Etanercept, a blocker of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α), is effective in the treatment of psoriasis. We aimed to evaluate the expression profiles of AMPs in psoriatic skin before and after a 6-week course of etanercept therapy. We included 12 psoriasis patients who underwent medium-dose etanercept treatment for 6weeks. At baseline and at the end of therapy immunohistochemistry from lesional skin was performed for psoriasin, LL-37, and human ß-defensin 2 (hBD-2). After 6-week treatment, the modified psoriasis area and severity index significantly decreased from 37.5±5.9 to 14±13. 4. Lesional immunoreactivity scores of psoriasin, LL-37, and hBD-2 also significantly decreased after a 6-week course of etanercept. We have demonstrated that etanercept-induced improvement of psoriasic lesions is associated with a significant decline of AMP protein expression.[1]

References

Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients. Gambichler, T., Kobus, S., Kobus, A., Tigges, C., Scola, N., Altmeyer, P., Kreuter, A., Bechara, F.G., Skrygan, M. Regul. Pept. (2011) [Pubmed]

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