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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Addiction circuitry in the human brain (*).

A major challenge in understanding substance-use disorders lies in uncovering why some individuals become addicted when exposed to drugs, whereas others do not. Although genetic, developmental, and environmental factors are recognized as major contributors to a person's risk of becoming addicted, the neurobiological processes that underlie this vulnerability are still poorly understood. Imaging studies suggest that individual variations in key dopamine-modulated brain circuits, including circuits involved in reward, memory, executive function, and motivation, contribute to some of the differences in addiction vulnerability. A better understanding of the main circuits affected by chronic drug use and the influence of social stressors, developmental trajectories, and genetic background on these circuits is bound to lead to a better understanding of addiction and to more effective strategies for the prevention and treatment of substance-use disorders.[1]

References

  1. Addiction circuitry in the human brain (*). Volkow, N.D., Wang, G.J., Fowler, J.S., Tomasi, D. Annu. Rev. Pharmacol. Toxicol. (2012) [Pubmed]
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