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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of ponsinomycin on cyclosporin pharmacokinetics.

The influence of treatment with ponsinomycin, a new macrolide antibiotic, on the pharmacokinetics of cyclosporin A has been studied in 10 renal transplant patients. The pharmacokinetics of cyclosporin A was investigated at steady state, before and during treatment with ponsinomycin. On average, the blood levels of cyclosporin A were doubled by the macrolide, possibly due to a decrease in elimination or/and to an increase in absorption. Ponsinomycin should be use very carefully in patients treated with cyclosporin A.[1]

References

  1. Effect of ponsinomycin on cyclosporin pharmacokinetics. Couet, W., Istin, B., Seniuta, P., Morel, D., Potaux, L., Fourtillan, J.B. Eur. J. Clin. Pharmacol. (1990) [Pubmed]
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