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Chemical Compound Review

Sandimmun     30-ethyl-33-[(Z,1S,2R)-1- hydroxy-2-methyl...

Synonyms: Consupren, Sandimmune, Ciclosporin, Cyclosporin, cyclosporine, ...
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Disease relevance of Sandimmun Neoral


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High impact information on Sandimmun Neoral

  • As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of activated T cells) family have been the focus of much attention [11].
  • Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction [12].
  • The effects of cyclosporin A on the immune system [13].
  • Calcineurin is potently inhibited by immunosuppressant drugs, cyclosporin A and FK506, in the presence of their respective cytoplasmic immunophilin proteins, cyclophilin and FK506-binding protein [14].
  • The prototypic members of the immunophilin family, cyclophilin A and FKPB12, were discovered on the basis of their ability to bind and mediate the immunosuppressive effects of the drugs cyclosporin, FK506, and rapamycin [15].

Chemical compound and disease context of Sandimmun Neoral


Biological context of Sandimmun Neoral


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Gene context of Sandimmun Neoral


Analytical, diagnostic and therapeutic context of Sandimmun Neoral


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