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Kodama, S. et al.

Shuji Kodama, Atsushi Taga, Sen-Ich Aizawa, Tomoko Kemmei, Yoshitaka Honda, Kentaro Suzuki, Atsushi Yamamoto, Atsushi Taga, Sen-Ich Aizawa, Tomoko Kemmei, Yoshitaka Honda, Kentaro Suzuki, Atsushi Yamamoto,

Direct enantioseparation of lipoic acid in dietary supplements by capillary electrophoresis using trimethyl-β-cyclodextrin as a chiral selector.

Lipoic acid, an antioxidant, naturally occurs as the (R)-enantiomer, while synthetic lipoic acid is racemic. It is thus of interest to know the (R)-enantiomer content of lipoic acid supplements. Here, we used capillary electrophoresis to directly enantioseparate lipoic acid in dietary supplements by using a sulfonated capillary with an effective voltage of +18 kV and direct detection at 200 nm. Factors affecting migration time and resolution of lipoic acid were investigated. The optimum background electrolyte was found to be 100 mM phosphate buffer (pH 7.0) containing 8 mM trimethyl-β-cyclodextrin as a chiral selector at 20°C. Under the proposed conditions, direct chiral resolution of lipoic acid in dietary supplements was conducted successfully.[1]

References

Direct enantioseparation of lipoic acid in dietary supplements by capillary electrophoresis using trimethyl-β-cyclodextrin as a chiral selector. Kodama, S., Taga, A., Aizawa, S.I., Kemmei, T., Honda, Y., Suzuki, K., Yamamoto, A. Electrophoresis (2012) [Pubmed]

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