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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bromide intoxication secondary to pyridostigmine bromide therapy.

The diagnosis of bromide intoxication is often aided by the detection of a low or negative anion gap due to the laboratory detection of bromide as chloride. A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication. The diagnosis was suspected in the setting of a negative anion gap and only later confirmed by direct measurement of the serum bromide level. To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.[1]


  1. Bromide intoxication secondary to pyridostigmine bromide therapy. Rothenberg, D.M., Berns, A.S., Barkin, R., Glantz, R.H. JAMA (1990) [Pubmed]
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