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Ganzera, M. et al.

Markus Ganzera, Viktoria Greifeneder, Stefan Schwaiger, Hermann Stuppner, Viktoria Greifeneder, Stefan Schwaiger, Hermann Stuppner,

Chemical profiling of Edelweiss (Leontopodium alpinum Cass.) extracts by micellar electrokinetic capillary chromatography.

This manuscript reports on the first CE-method suitable for analyzing twelve pharmacologically relevant compounds (flavonoids, caffeic acids and leontopodic acid) in the aerial parts of Leontopodium alpinum. By using a 60mM borax buffer containing 25mM SDS and 35% acetonitrile the analytes could be well resolved in 25min and accurately determined in different Edelweiss specimens. Method validation assured the compliance of the assay to ICH standards (correlation coefficients ≥0.999, LOD ≤7.2μg/ml, LOQ ≤23.0μg/ml, recovery rates from 96.6 to 101.1%, intermediate precision ≤7.01%, and repeatability ≤5.52%). The quantitative results revealed a strong dependence of the content of phenolics on the growth status of the plants. In early stages no flavonoids were found, while during blooming all metabolites reached higher levels; commercially cultivated plant material showed the overall highest values (flavonoids: 0.25-0.34%, caffeic acids: 4.99-6.21%, leontopodic acid: 4.21-5.05%).[1]

References

Chemical profiling of Edelweiss (Leontopodium alpinum Cass.) extracts by micellar electrokinetic capillary chromatography. Ganzera, M., Greifeneder, V., Schwaiger, S., Stuppner, H. Fitoterapia (2012) [Pubmed]

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