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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A pharmacokinetic study of high-dose metoclopramide suppositories.

The pharmacokinetics of high-dose rectal metoclopramide have been studied in nine patients after administration of 150-mg suppositories. The results have been compared to the pharmacokinetics of the drug in five patients who received the same dose of metoclopramide intravenously. Administration of a metoclopramide suppository achieved plasma drug concentrations that are associated with the effective treatment of cytotoxic drug-induced nausea and vomiting. In three patients who received the drug by both routes the systemic availability of the suppository appeared to be complete. High-dose metoclopramide suppositories are convenient and may be advantageous in the treatment of medical oncology out-patients.[1]

References

  1. A pharmacokinetic study of high-dose metoclopramide suppositories. Hardy, F., Warrington, P.S., MacPherson, J.S., Hudson, S.A., Jefferson, G.C., Smyth, J.F. Journal of clinical pharmacy and therapeutics. (1990) [Pubmed]
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