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Chemical Compound Review

Cerucal     4-amino-5-chloro-N-(2- diethylaminoethyl)-2...

Synonyms: Emitasol, Gastrese, Maxolon, Primperan, Reglan, ...
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Disease relevance of Maxolon


Psychiatry related information on Maxolon


High impact information on Maxolon


Chemical compound and disease context of Maxolon


Biological context of Maxolon


Anatomical context of Maxolon


Associations of Maxolon with other chemical compounds


Gene context of Maxolon

  • To determine whether dopaminergic inhibition contributed to the reduced TSH and PRL responsiveness in the acute withdrawal state, six additional chronic alcoholic men were tested with oral metoclopramide [29].
  • Insulin hypoglycemia stimulated and metoclopramide inhibited both GH and GHRH acutely [30].
  • In analogy to the TSH behavior, plasma PRL secretion in response to metoclopramide and TRH administration was significantly (p less than 0.05) inhibited in the subclinical hypothyroid patients after l-thyroxine replacement therapy [31].
  • This study aimed to evaluate PRL and GH secretion after metoclopramide and thyrotrophin-releasing hormone (TRH) infusion in infertile patients with minimal/mild endometriosis [32].
  • Metoclopramide is a potent inhibitor of CYP2D6 at therapeutically relevant concentrations (K(i) = 4.7 +/- 1.3 microM), with negligible effect on other isoforms tested [33].

Analytical, diagnostic and therapeutic context of Maxolon


  1. Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. Gralla, R.J., Itri, L.M., Pisko, S.E., Squillante, A.E., Kelsen, D.P., Braun, D.W., Bordin, L.A., Braun, T.J., Young, C.W. N. Engl. J. Med. (1981) [Pubmed]
  2. More on metoclopramide and tardive dyskinesia. Mahler, J.C., Brown, R.P. N. Engl. J. Med. (1987) [Pubmed]
  3. A controlled trial of metoclopramide in symptomatic gastroesophageal reflux. McCallum, R.W., Ippoliti, A.F., Cooney, C., Sturdevant, R.A. N. Engl. J. Med. (1977) [Pubmed]
  4. Hypertension after metoclopramide. Vogelzang, N.J. N. Engl. J. Med. (1983) [Pubmed]
  5. Ondansetron compared with dexamethasone and metoclopramide as antiemetics in the chemotherapy of breast cancer with cyclophosphamide, methotrexate, and fluorouracil. Levitt, M., Warr, D., Yelle, L., Rayner, H.L., Lofters, W.S., Perrault, D.J., Wilson, K.S., Latreille, J., Potvin, M., Warner, E. N. Engl. J. Med. (1993) [Pubmed]
  6. Akathisia and metoclopramide. Jungmann, E., Schöffling, K. Lancet (1982) [Pubmed]
  7. Gastric motor abnormalities in diabetic and postvagotomy gastroparesis: effect of metoclopramide and bethanechol. Malagelada, J.R., Rees, W.D., Mazzotta, L.J., Go, V.L. Gastroenterology (1980) [Pubmed]
  8. Absent postprandial duodenal motility in a child with cystic fibrosis. Correction of the symptoms and manometric abnormality with cisapride. Hyman, P.E. Gastroenterology (1986) [Pubmed]
  9. Can metoclopramide reveal Huntington's disease? Giroud, M., Fabre, J.L., Putelat, R., Caillot, X., Escousse, A., Nivelon-Chevalier, A., Dumas, R. Lancet (1982) [Pubmed]
  10. Sleeping with and without norepinephrine: effects of metoclopramide and D,L-threo-3,4-dihydroxyphenylserine on sleep in dopamine beta-hydroxylase deficiency. Tulen, J.H., Man in 't Veld, A.J., Dzoljic, M.R., Mechelse, K., Moleman, P. Sleep. (1991) [Pubmed]
  11. Urinary incontinence associated with metoclopramide. Kumar, B.B. JAMA (1984) [Pubmed]
  12. Combination of glucagon and low-dose metoclopramide in management of cisplatin-induced nausea and vomiting. Bindi, M., Pepi, F., Sebaste, L., Tucci, E., Pirtoli, L. J. Natl. Cancer Inst. (1988) [Pubmed]
  13. Oral metoclopramide with or without diphenhydramine: potential for prevention of late nausea and vomiting induced by cisplatin. Grunberg, S.M., Ehler, E., McDermed, J.E., Akerley, W.L. J. Natl. Cancer Inst. (1988) [Pubmed]
  14. Acute akathisia after oral droperidol and metoclopramide preoperative medication. Barnes, T.R., Braude, W.M., Hill, D.J. Lancet (1982) [Pubmed]
  15. Continuous versus intermittent infusion of high-dose metoclopramide in prevention of cisplatin-induced emesis. Egros, F., Dufour, A., Cazor, J. Lancet (1992) [Pubmed]
  16. Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. A comparison with metoclopramide and placebo. Feldman, M., Smith, H.J. Gastroenterology (1987) [Pubmed]
  17. Amiodarone, metoclopramide, and renal failure. Lloveras, J., Masramon, J., Aubia, J., Llorach, M. Lancet (1979) [Pubmed]
  18. Effects of metoclopramide and bethanechol on delayed gastric emptying present in gastroesophageal reflux patients. McCallum, R.W., Fink, S.M., Lerner, E., Berkowitz, D.M. Gastroenterology (1983) [Pubmed]
  19. Pharmacokinetics of metoclopramide. Bateman, D.N., Davies, D.S. Lancet (1979) [Pubmed]
  20. A dose response relation between improved lactation and metoclopramide. Kauppila, A., Kivinen, S., Ylikorkala, O. Lancet (1981) [Pubmed]
  21. Plasma motilin concentration and interdigestive migrating motor complex in diabetic gastroparesis: effect of metoclopramide. Achem-Karam, S.R., Funakoshi, A., Vinik, A.I., Owyang, C. Gastroenterology (1985) [Pubmed]
  22. Effects of different types of stress and of "prokinetic" drugs on the control of the fasting motor complex in humans. Valori, R.M., Kumar, D., Wingate, D.L. Gastroenterology (1986) [Pubmed]
  23. Mechanism of action of metoclopramide on opossum lower esophageal sphincter muscle. Cohen, S., DiMarino, A.J. Gastroenterology (1976) [Pubmed]
  24. Effect of oral metoclopramide on gastroesophageal reflux in the post-cibal state. Behar, J., Biancani, P. Gastroenterology (1976) [Pubmed]
  25. A double blind crossover study of metoclopramide versus placebo for facilitating passage of multipurpose biopsy tube. Christie, D.L., Ament, M.E. Gastroenterology (1976) [Pubmed]
  26. Metoclopramide to treat gastroparesis due to diabetes mellitus: a double-blind, controlled trial. Snape, W.J., Battle, W.M., Schwartz, S.S., Braunstein, S.N., Goldstein, H.A., Alavi, A. Ann. Intern. Med. (1982) [Pubmed]
  27. Intravenous metoclopramide. An effective antiemetic in cancer chemotherapy. Strum, S.B., McDermed, J.E., Opfell, R.W., Riech, L.P. JAMA (1982) [Pubmed]
  28. DA1 receptor mediates dopamine-induced relaxation of opossum lower esophageal sphincter in vitro. Lombardi, D.M., Grous, M., Fine, C.F., Barone, F.C., Fowler, P.J., Phyall, W.B., Rush, J.A., Ormsbee, H.S. Gastroenterology (1986) [Pubmed]
  29. Prolactin and thyrotropin responses to thyrotropin-releasing hormone and metoclopramide in men with chronic alcoholism. Röjdmark, S., Adner, N., Andersson, D.E., Austern, J., Lamminpää, K. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  30. Acromegaly due to ectopic growth hormone (GH)-releasing hormone (GHRH) production: dynamic studies of GH and ectopic GHRH secretion. Barkan, A.L., Shenker, Y., Grekin, R.J., Vale, W.W., Lloyd, R.V., Beals, T.F. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  31. Prolactin and TSH response to TRH and metoclopramide before and after l-thyroxine therapy in subclinical hypothyroidism. Lombardi, G., Iodice, M., Miletto, P., Merola, B., Panza, N., Annunziato, L. Neuroendocrinology (1986) [Pubmed]
  32. Prolactin and growth hormone secretion after thyrotrophin-releasing hormone infusion and dopaminergic (DA2) blockade in infertile patients with minimal/mild endometriosis. Cunha-Filho, J.S., Gross, J.L., Lemos, N.A., Dias, E.C., Vettori, D., Souza, C.A., Passos, E.P. Hum. Reprod. (2002) [Pubmed]
  33. The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6. Desta, Z., Wu, G.M., Morocho, A.M., Flockhart, D.A. Drug Metab. Dispos. (2002) [Pubmed]
  34. Gastric and esophageal emptying in dystrophia myotonica. Effect of metoclopramide. Horowitz, M., Maddox, A., Maddern, G.J., Wishart, J., Collins, P.J., Shearman, D.J. Gastroenterology (1987) [Pubmed]
  35. Gastric emptying in patients with diabetes mellitus. Loo, F.D., Palmer, D.W., Soergel, K.H., Kalbfleisch, J.H., Wood, C.M. Gastroenterology (1984) [Pubmed]
  36. Effect of metoclopramide in chronic gastric retention after gastric surgery. Metzger, W.H., Cano, R., Sturdevant, R.A. Gastroenterology (1976) [Pubmed]
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