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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Structural organization of the hCTLA-1 gene encoding human granzyme B.

Cytotoxic T lymphocytes (CTLs) and natural killer/lymphokine-activated cells produce granzymes, a family of serine esterase proteins located in cytoplasmic granules. These might be involved in different cytotoxic pathways. We report the structural organization of the human gene encoding granzyme B (hCTLA-1). A 4.75-kb genomic DNA fragment containing all the sequences of granzyme B-encoding cDNA clones has been sequenced. The gene is composed of five exons and four introns. A comparison with the genomic organization of murine CCP1/ CTLA-1 showed very similar structure and a 76% nucleotide homology in the coding sequences. This suggests that both genes may have a common ancestor. No typical regulatory element was detected in the 1160 bp upstream from the ATG start codon. The detection of a second locus related to hCTLA-1 is also described.[1]


  1. Structural organization of the hCTLA-1 gene encoding human granzyme B. Haddad, P., Clément, M.V., Bernard, O., Larsen, C.J., Degos, L., Sasportes, M., Mathieu-Mahul, D. Gene (1990) [Pubmed]
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