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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Protection of Toxoplasma gondii-infected mice by stearylamine-bearing liposomes.

The cytotoxic activity of stearylamine-bearing liposomes against Toxoplasma gondii (RH strain) was examined. When tachyzoites were treated in vitro with liposomes consisting of 20 mol% stearylamine and 80 mol% phosphatidylcholine (130 micrograms/ml total lipids), more than 95% of the parasites were killed within 90 min. Intraperitoneal injection of 10 mg of 30 mol% stearylamine/70 mol% phosphatidylcholine-liposomes in mice shortly before or after T. gondii challenge afforded protection from death for more than 30 days to 70-80% of the treated mice, whereas all untreated mice succumbed within 9 days. The liposome-injected mice that survived remained symptom-free and behaved normally.[1]


  1. Protection of Toxoplasma gondii-infected mice by stearylamine-bearing liposomes. Tachibana, H., Yoshihara, E., Kaneda, Y., Nakae, T. J. Parasitol. (1990) [Pubmed]
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