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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Time-dependent effects of chloroquine on pH of hepatocyte lysosomes.

In vivo administration of chloroquine to rats caused an increase in the pH of hepatocyte lysosomes within 1 hr after administration with a return to baseline pH values by 3 hr; continued administration of chloroquine for up to 12 days was unaccompanied by any further changes in hepatocyte lysosomal pH. We interpret these data as evidence against a major role for an increase in the pH of hepatocyte lysosomes in CAC-induced phospholipidosis.[1]

References

  1. Time-dependent effects of chloroquine on pH of hepatocyte lysosomes. Tietz, P.S., Yamazaki, K., LaRusso, N.F. Biochem. Pharmacol. (1990) [Pubmed]
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