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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Respiratory arrest after a caudal injection of bupivacaine.

A 3.5-year-old child with Cornelia de Lange syndrome presenting for orchidopexy and herniotomy received general anaesthesia which was supplemented by a caudal injection of bupivacaine. Shortly after this he had a respiratory arrest with fixed dilated pupils. No cardiovascular system instability was observed. Approximately one hour later the child made a rapid and complete recovery. The possible causes of these events are discussed with particular reference to the potential effects of caudal injections on intracranial pressure.[1]


  1. Respiratory arrest after a caudal injection of bupivacaine. Lumb, A.B., Carli, F. Anaesthesia. (1989) [Pubmed]
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