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MeSH Review

Intracranial Pressure

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Disease relevance of Intracranial Pressure


Psychiatry related information on Intracranial Pressure


High impact information on Intracranial Pressure


Chemical compound and disease context of Intracranial Pressure


Biological context of Intracranial Pressure


Anatomical context of Intracranial Pressure


Associations of Intracranial Pressure with chemical compounds


Gene context of Intracranial Pressure

  • In addition to enhanced leukocyte infiltration into the CSF, meningitis-associated intracranial complications including blood-brain barrier disruption and the rise in intracranial pressure were significantly augmented in infected eNOS-deficient mice [32].
  • Thus, we investigated early changes in the concentrations of CSF S100B and various cytokines after TBI and evaluated the relations of both S100B and cytokines to intracranial pressure (ICP) and prognosis [33].
  • The dynamics of the ET-1 concentration changes observed in rats with blocked ETA receptor suggests that SAH is an ET-1 production stimulator significantly more potent than other factors assessed in the study, such as a rise in the intracranial pressure resulting from administering aCSF to CM [34].
  • However, at 3 days the AQP4 null mice had significantly higher intracranial pressure (mean +/- SEM 27 +/- 2 vs. 17 +/- 2 mmHg; p < 0.001) and brain water content (81.0 +/- 0.3 vs. 79.3 +/- 0.5 % water by weight in the abscess-containing hemisphere; p < 0.01) than wild-type mice [35].
  • Serum gastrin levels were normal in both groups and did not correlate with intracranial pressure [36].

Analytical, diagnostic and therapeutic context of Intracranial Pressure


  1. Transforming growth factor beta 2 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor alpha-independent early phase of experimental pneumococcal meningitis. Pfister, H.W., Frei, K., Ottnad, B., Koedel, U., Tomasz, A., Fontana, A. J. Exp. Med. (1992) [Pubmed]
  2. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Paul, R., Lorenzl, S., Koedel, U., Sporer, B., Vogel, U., Frosch, M., Pfister, H.W. Ann. Neurol. (1998) [Pubmed]
  3. Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin. Clemmesen, J.O., Hansen, B.A., Larsen, F.S. Hepatology (1997) [Pubmed]
  4. The use of drugs in emergency airway management in pediatric trauma. Nakayama, D.K., Waggoner, T., Venkataraman, S.T., Gardner, M., Lynch, J.M., Orr, R.A. Ann. Surg. (1992) [Pubmed]
  5. Mannitol-induced acute renal failure. Visweswaran, P., Massin, E.K., Dubose, T.D. J. Am. Soc. Nephrol. (1997) [Pubmed]
  6. Limitations of the Glasgow Coma Scale in predicting outcome in children with traumatic brain injury. Lieh-Lai, M.W., Theodorou, A.A., Sarnaik, A.P., Meert, K.L., Moylan, P.M., Canady, A.I. J. Pediatr. (1992) [Pubmed]
  7. Concentration of 3', 5' cyclic adenosine monophosphate in ventricular cerebrospinal fluid of patients with prolonged coma after head trauma or intracranial hemorrhage. Rudman, D., Fleischer, A., Kutner, M.H. N. Engl. J. Med. (1976) [Pubmed]
  8. Neuroendocrine abnormalities in patients with traumatic brain injury. Yuan, X.Q., Wade, C.E. Frontiers in neuroendocrinology. (1991) [Pubmed]
  9. Effect of recombinant human tumor necrosis factor-alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: role of nitric oxide. Tureen, J. J. Clin. Invest. (1995) [Pubmed]
  10. Brain edema and intracranial hypertension in rats after total hepatectomy. Olafsson, S., Gottstein, J., Blei, A.T. Gastroenterology (1995) [Pubmed]
  11. Intracerebroventricular pressure inhibits gastric antral and duodenal contractility but not acid secretion in conscious rabbits. Garrick, T., Mulvihill, S., Buack, S., Maeda-Hagiwara, M., Tache, Y. Gastroenterology (1988) [Pubmed]
  12. Brain edema in rabbits with galactosamine-induced fulminant hepatitis. Regional differences and effects on intracranial pressure. Traber, P.G., Ganger, D.R., Blei, A.T. Gastroenterology (1986) [Pubmed]
  13. Clinical monitoring of intracranial pressure in fulminant hepatic failure. Hanid, M.A., Davies, M., Mellon, P.J., Silk, D.B., Strunin, L., McCabe, J.J., Williams, R. Gut (1980) [Pubmed]
  14. Benign intracranial hypertension during prednisolone treatment for inflammatory bowel disease. Newton, M., Cooper, B.T. Gut (1994) [Pubmed]
  15. Doppler CO2 test as an indicator of cerebral vasoreactivity and prognosis in severe intracranial hemorrhages. Klingelhöfer, J., Sander, D. Stroke (1992) [Pubmed]
  16. Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs. Hurn, P.D., Koehler, R.C., Blizzard, K.K., Traystman, R.J. Stroke (1995) [Pubmed]
  17. Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis. Paul, R., Koedel, U., Winkler, F., Kieseier, B.C., Fontana, A., Kopf, M., Hartung, H.P., Pfister, H.W. Brain (2003) [Pubmed]
  18. Treatment of systemic hypertension and intracranial hypertension in cases of brain hemorrhage. Hayashi, M., Kobayashi, H., Kawano, H., Handa, Y., Hirose, S. Stroke (1988) [Pubmed]
  19. In vivo effects of alpha-adrenoceptor agonists and antagonists on pial veins of cats. Ulrich, K., Kuschinsky, W. Stroke (1985) [Pubmed]
  20. Cerebral blood flow and intracranial pressure in the dog during intravenous infusion of nitroglycerin alone and in combination with dopamine. von Essen, C., Kistler, J.P., Lees, R.S., Zervas, N.T. Stroke (1981) [Pubmed]
  21. Characterization of the cardiac effects of acute subarachnoid hemorrhage in dogs. Elrifai, A.M., Bailes, J.E., Shih, S.R., Dianzumba, S., Brillman, J. Stroke (1996) [Pubmed]
  22. Cerebrospinal fluid vasopressin and increased intracranial pressure. Sørensen, P.S., Gjerris, F., Hammer, M. Ann. Neurol. (1984) [Pubmed]
  23. Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide. Koedel, U., Bernatowicz, A., Paul, R., Frei, K., Fontana, A., Pfister, H.W. Ann. Neurol. (1995) [Pubmed]
  24. Loss of adrenocortical suppression after acute brain injury: role of increased intracranial pressure and brain stem function. Feibel, J., Kelly, M., Lee, L., Woolf, P. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  25. Influence of granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentrations of lactate and protein in experimental meningitis. Täuber, M.G., Borschberg, U., Sande, M.A. J. Infect. Dis. (1988) [Pubmed]
  26. Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Angstwurm, K., Hanisch, U.K., Gassemi, T., Bille, M.B., Prinz, M., Dirnagl, U., Kettenmann, H., Weber, J.R. Infect. Immun. (2004) [Pubmed]
  27. Intracranial pressure in pigs with surgically induced acute liver failure. Hanid, M.A., Mackenzie, R.L., Jenner, R.E., Chase, R.A., Mellon, P.J., Trewby, P.N., Janota, I., Davis, M., Silk, D.B., Williams, R. Gastroenterology (1979) [Pubmed]
  28. gamma-Hydroxybutyric acid and intracranial pressure. Strong, A.J. Lancet (1984) [Pubmed]
  29. Restoration of cerebrovascular CO2 responsivity by glutamine synthesis inhibition in hyperammonemic rats. Takahashi, H., Koehler, R.C., Hirata, T., Brusilow, S.W., Traystman, R.J. Circ. Res. (1992) [Pubmed]
  30. Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure. Lidofsky, S.D., Bass, N.M., Prager, M.C., Washington, D.E., Read, A.E., Wright, T.L., Ascher, N.L., Roberts, J.P., Scharschmidt, B.F., Lake, J.R. Hepatology (1992) [Pubmed]
  31. Thiopental infusion in the treatment of intracranial hypertension complicating fulminant hepatic failure. Forbes, A., Alexander, G.J., O'Grady, J.G., Keays, R., Gullan, R., Dawling, S., Williams, R. Hepatology (1989) [Pubmed]
  32. Lack of endothelial nitric oxide synthase aggravates murine pneumococcal meningitis. Koedel, U., Paul, R., Winkler, F., Kastenbauer, S., Huang, P.L., Pfister, H.W. J. Neuropathol. Exp. Neurol. (2001) [Pubmed]
  33. Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Hayakata, T., Shiozaki, T., Tasaki, O., Ikegawa, H., Inoue, Y., Toshiyuki, F., Hosotubo, H., Kieko, F., Yamashita, T., Tanaka, H., Shimazu, T., Sugimoto, H. Shock (2004) [Pubmed]
  34. Influence endothelin ETA receptor antagonist--BQ-123--on changes of endothelin-1 level in plasma of rats with acute vasospasm following subarachnoid hemorrhage. Jośko, J., Hendryk, S., Jedrzejowska-Szypuła, H., Gwóźdź, B., Herman, Z.S., Gawlik, R. J. Physiol. Pharmacol. (1998) [Pubmed]
  35. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. Bloch, O., Papadopoulos, M.C., Manley, G.T., Verkman, A.S. J. Neurochem. (2005) [Pubmed]
  36. Gastric response to severe head injury. Larson, G.M., Koch, S., O'Dorisio, T.M., Osadchey, B., McGraw, P., Richardson, J.D. Am. J. Surg. (1984) [Pubmed]
  37. The role of hypothermia in the management of severe brain injury: a meta-analysis. Harris, O.A., Colford, J.M., Good, M.C., Matz, P.G. Arch. Neurol. (2002) [Pubmed]
  38. Fluid thresholds and outcome from severe brain injury. Clifton, G.L., Miller, E.R., Choi, S.C., Levin, H.S. Crit. Care Med. (2002) [Pubmed]
  39. Bronchoconstrictive and relaxant effects of lidocaine on the airway in dogs. Hirota, K., Hashimoto, Y., Sato, T., Yoshioka, H., Kudo, T., Matsuki, A., Lambert, D.G. Crit. Care Med. (2001) [Pubmed]
  40. Effects of hyperbaric treatment in cerebral air embolism on intracranial pressure, brain oxygenation, and brain glucose metabolism in the pig. van Hulst, R.A., Drenthen, J., Haitsma, J.J., Lameris, T.W., Visser, G.H., Klein, J., Lachmann, B. Crit. Care Med. (2005) [Pubmed]
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