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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload.

In rats with chronic dietary iron overload, a higher amount of liver ferritin L-subunit mRNA was found mainly engaged on polysomes, whereas in control rats ferritin L-subunit mRNA molecules were largely stored in ribonucleoprotein particles. On the other hand, ferritin H-subunit mRNA was unchanged by chronic iron load and remained in the inactive cytoplasmic pool. In agreement with previous reports, in rats acutely treated with parenteral iron, only the ferritin L-subunit mRNA increased in amount, whereas both ferritin subunit mRNAs shifted to polysomes. This may indicate that, whereas in acute iron overload the hepatocyte operates a translation shift of both ferritin mRNAs to confront rapidly the abrupt entry of iron into the cell, during chronic iron overload it responds to the slow iron influx by translating a greater amount of L-subunit mRNA to synthesize isoferritins more suitable for long-term iron storage.[1]

References

  1. Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload. Cairo, G., Tacchini, L., Schiaffonati, L., Rappocciolo, E., Ventura, E., Pietrangelo, A. Biochem. J. (1989) [Pubmed]
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